Antiretroviral therapy improves neurocognitive impairment in people living with HIV? A meta-analysis

作     者：Chang Gao Jingjing Meng Xueling Xiao Min Wang Ann Barterley Williams Honghong Wang Chang Gao;Jingjing Meng;Xueling Xiao;Min Wang;Ann Barterley Williams;Honghong Wang

作者机构：Xiangya School of NursingCentral South UniversityHunanChina The Institute of HIV/AIDSThe First Hospital in ChangshaHunanChina Rory Meyers College of NursingNew York UniversityNew YorkUSA 

出 版 物：《International Journal of Nursing Sciences》 (国际护理科学（英文）)

年 卷 期：2020年第7卷第2期

页      面：238-247页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Anti-retroviral agents Cognition Cognitive dysfunction HIV infections Neurocognitive disorders 

摘      要：Objectives:Although effective antiretroviral therapy(ART)has been used for more than two decades,HIV-associated neurocognitive disorder remains ***,whether ART can improve neurocognitive impairment is *** review aims to explore the effects of ART on cognitive impairment in people living with HIV(PLWH).Methods:A systematic literature search was conducted in eight databases(PubMed,Embase,Web of Science,Cochrane Library,CNKI,VIP,China Biology Medicine disc,and WanFang)to identify studies that compare cognitive function between study groups who are administered and not administered *** searched for articles published up to April *** evaluation and data extraction were independently conducted by two ***:Sixteen articles(6,694 participants)-14 cross-sectional studies and 2 cohort studies—were included in this *** cross-sectional studies demonstrated that ART group did not perform better than the non-ART group(OR=1.16;95%CI,1.03-1.30).However,the cohort studies reported a significant improvement in cognitive function at three months(OR=4.01;95%CI,2.35-6.85)and six months(OR=9.24;95%CI,1.71-49.96)after ART initiation compared with the baseline *** significant cognitive improvement was found in participants younger than 55 years old,but the two crosssectional studies showed that ART may improve cognitive function in PLWH under 65 years old with poor physical condition and immune ***:ART could improve cognitive function in PLWH with poor physical condition and immune status,but it does not considerably improve cognition in the entire PLWH population.