Ability of human umbilical cord mesenchymal stem cells to repair chemotherapy-induced premature ovarian failure
作者机构：Department of Obstetrics and GynecologyGeneral Hospital of Northern Theater Command(Heping Campus)Shenyang 110000Liaoning ProvinceChina
出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)
年 卷 期：2020年第12卷第4期
页 面：277-287页
核心收录：
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
主 题：Umbilical cord mesenchymal stem cells Premature ovarian failure Chemotherapy Repair Ovarian injury Endocrine function
摘 要：BACKGROUND Premature ovarian insufficiency(POI)and premature ovarian failure(POF)have become one of the major problems threatening women of childbearing *** have shown that stem cells transplanted from bone marrow,umbilical cord,peripheral blood and amniotic fluid can migrate and proliferate to the ovary,promote ovarian function repair,increase the number of follicles and granulosa cells at all levels of ovary,improve endocrine function,and can differentiate into oocytes in specific ovarian environment to restore fertility to some *** To study the ability of human umbilical cord mesenchymal stem cells(hUCMSCs)to repair ovarian injury after *** A total of 110 female BALB/c mice(aged 7-8 wk old)with body masses of 16.0-20.0 g were *** mice were fed until 12 wk of age,and cyclophosphamide was administered by intraperitoneal injection for 14 consecutive days to induce premature ovarian failure in ***-five mice with estrous cycle disorder were screened and randomly divided into 3 groups according to their body weight:model group,positive control group and hUCMSC group,and each group had 25 *** 25 mice were used as negative *** mice in the hUCMSC group were injected with hUCMSCs in the tail vein,and the mice in the positive control group were given an oestradiol valerate solution and a medroxyprogesterone acetate solution in the tail *** the 1^st,15^th,30^th,45^th,and 60^th days after intravenous administration,vaginal smears were made to monitor the estrous cycles of the *** ovaries were weighed,and pathological sections were made to observe the morphology of the follicles;blood samples were collected to monitor the concentration of sex hormones(oestradiol and follicle-stimulating hormone).RESULTS The estrous cycles of the model group mice were disrupted throughout the *** in the hUCMSC group and the positive control group resumed normal estrous *** ovarian weight of the model
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