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Optimization Design of the Multi-Layer Cross-Sectional Layout of An umbilical Based on the GA-GLM

China Ocean Engineering 2024年第2期38卷 247-254页

作者： YANG Zhi-xun YIN Xu FAN Zhi-rui YAN Jun LU Yu-cheng SU Qi MAO Yandong WANG Hua-lin Institute of marine machinery College of Mechanical and Electrical EngineeringHarbin Engineering UniversityHarbin 150001China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDepartment of Engineering MechanicsDalian University of TechnologyDalian 116024China Ningbo Institube of Dalian University of Technology Ningbo 315040China

Marine umbilical is one of the key equipment for subsea oil and gas exploitation,which is usually integrated by a great number of different functional components with multi-layers.The layout of these components directly affects manufacturing,operation and storage performances of the umbilical.For the multi-layer cross-sectional layout design of the umbilical,a quantifiable multi-objective optimization model is established according to the operation and storage requirements.Considering the manufacturing factors,the multi-layering strategy based on contact point identification is introduced for a great number of functional components.Then,the GA-GLM global optimization algorithm is proposed combining the genetic algorithm and the generalized multiplier method,and the selection operator of the genetic algorithm is improved based on the steepest descent method.Genetic algorithm is used to find the optimal solution in the global space,which can converge from any initial layout to the feasible layout solution.The feasible layout solution is taken as the initial value of the generalized multiplier method for fast and accurate solution.Finally,taking umbilicals with a great number of components as examples,the results show that the cross-sectional performance of the umbilical obtained by optimization algorithm is better and the solution efficiency is higher.Meanwhile,the multi-layering strategy is effective and feasible.The design method proposed in this paper can quickly obtain the optimal multi-layer cross-sectional layout,which replaces the manual design,and provides useful reference and guidance for the umbilical industry.

关键词： umbilical cross-sectional layout multi-layers GA-GLM optimization

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Effects of Ginsenoside Re on Ox-LDL-induced MEK/ERK/NF-κB signaling pathway in human umbilical vein endothelial cells

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 16-16页

作者：陈莉 Natl Clin Cardiol Res Center Xiyuan HospChin CM AcadBeijing 100091

Objective To explore the effects of Ginsenoside Re(G-Re) on oxidized low density lipoprotein (ox-LDL)-induced inflammatory response via mitogen-activated protein kinase/extracellular regulated protein kinases/nuclear factor kappa-B (MEK/ERK/NF-κB) signaling pathway in human umbilical vein endothelial cells(HUVECs).Methods HUVECs were cultured in vitro.

关键词： MEK/ERK lipoprotein umbilical

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Dwell time and bloodstream infection incidence of umbilical venous catheterization in China

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Pediatric Investigation 2023年第4期7卷 239-246页

作者： Xu Zheng Dan He Zixin Yang Lu Chen Min Jiang Yujie Qi Fei Qin Jie Yu Yaguang Peng Ling Liu Mingyan Hei Neonatal Center Beijing Children’s HospitalCapital Medical UniversityNational Center of Children’s HealthBeijingChina Guiyang Maternal and Child Health Care Hospital Guiyang Children’s HospitalGuizhouChina Center for Clinical Epidemiology and Evidence-based Medicine Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina 4Key Laboratory of Major Diseases in ChildrenMinistry of EducationBeijingChina

Importance:Central line-associated bloodstream infection(CLABSI)is one of the most serious complications of central venous access devices.Reducing the risk of CLABSI is of utmost significance in efforts to improve neonatal mortality rates and enhance long-term prognosis.Objective:To determine the dwell time and incidence of CLABSI of umbilical venous catheterization(UVC)for preterm infants in China.Methods:Preterm infants with UVC admitted to 44 tertiary neonatal intensive care units in 24 provinces in China were enrolled.Study period was from November 2019 to August 2021.The end point of observations was 48 h after umbilical venous(UV)catheter removal.The primary outcomes were dwell time of UV catheter and UVC-associated CLABSI.Data between infants with UV catheter dwell time≤7 days and>7 days,and with birth weight(BW)≤1000 g and>1000 g were compared.Results:In total,2172 neonates were enrolled(gestational age 30.0±2.4 weeks,BW 1258.5±392.8 g).The median UV catheter dwell time was 7(6–10)days.The incidence of UVC-associated CLABSI was 3.03/1000 UV catheter days.For infants with UV catheter dwell time≤7 days and>7 days,the UVC-associated CLABSI incidence was 3.71 and 2.65 per 1000 UV catheter days,respectively,P=0.23.For infants with UVC dwell times of 3–6,7–12,and 13–15 days,the UVC-associated CLABSI rates were 0.14%,0.68%,and 2.48%(P1000 g(P=0.60).Interpretation:The median dwell time of UV catheter was 7 days,and the incidence of UVC-associated CLABSI was 3.03/1000 catheter days in China.The daily risk of UVC-associated CLABSI and other complications increased with the dwell time.

关键词： Central line Dwell time Infection Newborn umbilical

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Analysis of ultrasound clinical early warning system in hyper-coiling umbilical cord

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Chinese Medical Journal 2023年第20期136卷 2516-2517页

作者： Junshu Xie Yani Yan Zhenjuan Yang Yuntao Li Xiaowei Xue Xiaohong Zhang Qiuyan Pei Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China

To the Editor:The umbilical cord is the vital link between the fetus and the placenta.The proper spiral state of the umbilical cord plays a key role in maintaining its function.The umbilical coiling index(UCI)is the number of spiral cycles per 1 cm of length and is normally 0.17,with UCI>0.30 considered hyper-coiling.^([1])Previous studies have identified hyper-coiling umbilical cord significantly associated with adverse pregnancy outcomes.^([2])However,many other studies have failed to find a strong correlation between abnormal coiling and adverse outcomes.^([3])Whether there are other abnormal ultrasound indicators in the hyper-coiling cord(HC)that can give early warning of adverse pregnancy still needs to be further explored.

关键词： fetus pregnancy umbilical

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Identification of microRNAs and messenger RNAs involved in human umbilical cord mesenchymal stem cell treatment of ischemic cerebral infarction using integrated bioinformatics analysis

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Neural Regeneration Research 2019年第9期14卷 1610-1616页

作者： Yin-Meng Qu Xin Sun Xiu-Li Yan Hang Jin Zhen-Ni Guo Yi Yang Stroke Center Neuroscience CenterDepartment of Neurologythe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Clinical Trial and Research Center for Stroke Department of Neurologythe First Hospital of Jilin UniversityChangchunJilin ProvinceChina

In recent years,a large number of differentially expressed genes have been identified in human umbilical cord mesenchymal stem cell(hUMSC)transplants for the treatment of ischemic cerebral infarction.These genes are involved in various biochemical processes,but the role of microRNAs(miRNAs)in this process is still unclear.From the Gene Expression Omnibus(GEO)database,we downloaded two microarray datasets for GSE78731(messenger RNA(mRNA)profile)and GSE97532(miRNA profile).The differentially expressed genes screened were compared between the hUMSC group and the middle cerebral artery occlusion group.Gene ontology enrichment and pathway enrichment analyses were subsequently conducted using the online Database for Annotation,Visualization,and Integrated Discovery.Identified genes were applied to perform weighted gene co-suppression analyses,to establish a weighted co-expression network model.Furthermore,the protein-protein interaction network for differentially expressed genes from turquoise modules was built using Cytoscape(version 3.40)and the most highly correlated subnetwork was extracted from the protein-protein interaction network using the MCODE plugin.The predicted target genes for differentially expressed miRNAs were also identified using the online database starBase v3.0.A total of 3698 differentially expressed genes were identified.Gene ontology analysis demonstrated that differentially expressed genes that are related to hUMSC treatment of ischemic cerebral infarction are involved in endocytosis and inflammatory responses.We identified 12 differentially expressed miRNAs in middle cerebral artery occlusion rats after hUMSC treatment,and these differentially expressed miRNAs were mainly involved in signaling in inflammatory pathways,such as in the regulation of neutrophil migration.In conclusion,we have identified a number of differentially expressed genes and differentially expressed mRNAs,miRNA-mRNAs,and signaling pathways involved in the hUMSC treatment of ischemic cerebral infarction.Bioinformatics and

关键词： nerve regeneration ischemic cerebral infarction human umbilical cord mesenchymal stem cell treatment bioinformatics analysis differentially expressed genes differentially expressed mRNAs inflammatory response stem cell therapy weighted gene co-suppression analysis WGCNA protein-protein interaction network PPI hUMSC neural regeneration

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Human umbilical cord mesenchymal stem cells ameliorate liver fibrosis in vitro and in vivo: From biological characteristics to therapeutic mechanisms

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World Journal of Stem Cells 2019年第8期11卷 548-564页

作者： Fei Yin Wen-Ying Wang Wen-Hua Jiang Department of Histology and Embryology Basic Medical College of Jilin University

Liver fibrosis is a wound-healing response to chronic injuries, characterized by the excessive accumulation of extracellular matrix or scar tissue within the liver;in addition, its formation is associated with multiple cytokines as well as several cell types and a variety of signaling pathways. When liver fibrosis is not well controlled, it can progress to liver cirrhosis, but it is reversible in principle. Thus far, no efficient therapy is available for treatment of liver fibrosis. Although liver transplantation is the preferred strategy, there are many challenges remaining in this approach, such as shortage of donor organs, immunological rejection, and surgical complications. Hence, there is a great need for an alternative therapeutic strategy. Currently, mesenchymal stem cell (MSC) therapy is considered a promising therapeutic strategy for the treatment of liver fibrosis;advantageously, the characteristics of MSCs are continuous self-renewal, proliferation, multipotent differentiation, and immunomodulatory activities. The human umbilical cord-derived (hUC)-MSCs possess not only the common attributes of MSCs but also more stable biological characteristics, relatively easy accessibility, abundant source, and no ethical issues (e.g., bone marrow being the adult source), making hUC-MSCs a good choice for treatment of liver fibrosis. In this review, we summarize the biological characteristics of hUC-MSCs and their paracrine effects, exerted by secretion of various cytokines, which ultimately promote liver repair through several signaling pathways. Additionally, we discuss the capacity of hUC-MSCs to differentiate into hepatocyte-like cells for compensating the function of existing hepatocytes, which may aid in amelioration of liver fibrosis. Finally, we discuss the current status of the research field and its future prospects.

关键词： Human umbilical cord mesenchymal stem cells Liver fibrosis Hepatocytelike cells Mechanism Cell therapy Paracrine effect Exosome Transdifferentiation

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Experimental treatment of radiation pneumonitis with human umbilical cord mesenchymal stem cells

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Asian Pacific Journal of Tropical Medicine 2014年第4期7卷 262-266页

作者： Rui Wang Chang-zheng Zhu Ping Qiao Jian Liu Qiang Zhao Kui-jie Wang Ting-bao Zhao Department of Spinal Cord Repairing Jinan Miliary General Hospital Department of Neurology People's Hospital of Zhangqiu Department of Orthopedics People's Hospital of Zhangqiu

Objective:To evaluate of the curative effect of human umbilical cord mesenchymal stem cells(hUC-MSCs)on rat acute radiation pneumonitis.Methods:Fourty rats were randomly divided into control group,radiation group,stem cell prevention group,stem cell treatment group and prednisone treatment group.All rats except those in the control group were radiated with X ray to establish the acute radiation pneumonitis damage model.The hUC-MSCs cultured in vitro was administrated to the rats of the prevention group via tail vein(1×10~6 cells/kg BW)24 h before the radiation,while the same administration was performed in the rats of the treatment group 24 h after the radiation.After 24 h post the radiation,the rats in tbe radiation group were given 0.4 mL physiological saline,and those in the prednisone group were given 1 mg/kg prednisone.All rats were,observed and executed 72 h after the radiation to defect lung histological changes.Results:After the administration of hUC-MSCs,the survival status of the rats in the prevention group and treatment group was obviously better than that in the control group.As shown by the histological staining,the morphology,proliferation activity aad bronchial state of lung tissues were better in the prevention group and treatment group than in the control group.Conclusion:The hUC-MSCs have definite therapeutic effects on acute radiation pneumonitis in rats.

关键词： Human umbilical cord mesenchymal stem cell Radiation pneumonitis Rat

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The effects of microRNA-34a regulating Notch-1/NF-κB signaling pathway on lipopolysaccharide-induced human umbilical vein endothelial cells

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World Journal of Emergency Medicine 2017年第4期8卷 292-296页

作者： Yun Ge Man Huang Yue-feng Ma Department of General Intensive Care Unit The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310052China

BACKGROUND: Notch-1/NF-κB signaling plays a key role in the cecal ligation and puncture(CLP)-induced sepsis. This study aims to investigate the intervention effects of microRNA-34a(miR-34a) lentivirus regulating Notch-1/NF-κB signaling pathway on lipopolysaccharide(LPS)-induced human umbilical vein endothelial cells(HUVEC).METHODS: HUVEC were divided into four groups as the following: they were infected with negative control lentivirus(NC group) or miR-34a lentivirus(OE group); LPS(1 g/mL) was added on the third day on the basis of NC group and OE group for 24 hours(NC+LPS group or OE+LPS group). The levels of TNF-α, IL-1β, IL-6, and IL-10 in the cell supernatants, and the mRNA and protein expression of Notch-1 and NF-κB in the HUVEC were evaluated.RESULTS: After 24 hours, the levels of TNF-α, IL-1β, IL-6 in the cell supernatants and the protein expression of NF-κB from NC+LPS group were significantly higher than those of NC group, but IL-10 level and the protein expression of Notch-1 in NC+LPS group were the opposite. After intervention of miR-34a lentivirus, the cell supernatants TNF-α and the protein expression of NF-κB in OE+LPS group after 24 hours markedly decreased compared to NC+LPS group. While the cell supernatants IL-1β and IL-6 and the mRNA expression of NF-κB slightly decreased in OE+LPS group, IL-10 and the mRNA and protein expression of Notch-1 were the opposite.CONCLUSION: miR-34a regulating Notch-1/NF-κB signaling pathway can reduce the HUVEC damage caused by LPS stimulation.

关键词： MicroRNA-34a Notch-1 NF-κB Lentivirus Human umbilical vein endothelial cells

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Human umbilical cord derived mesenchymal stem cells in peripheral nerve regeneration

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World Journal of Stem Cells 2020年第4期12卷 288-302页

作者： Christine Bojanic Kendrick To Bridget Zhang Christopher Mak Wasim S Khan Department of Plastic and Reconstructive Surgery Cambridge University Hospitals NHS TrustCambridge CB20QQUnited Kingdom Division of Trauma and Orthopaedic Surgery Addenbrooke's HospitalUniversity of CambridgeCambridge CB20QQUnited Kingdom School of Clinical Medicine University of CambridgeCambridge CB20QQUnited Kingdom

BACKGROUND Peripheral nerve injury can occur as a result of trauma or disease and carries significant morbidity including sensory and motor loss.The body has limited ability for nerve regeneration and functional recovery.Left untreated,nerve lesions can cause lifelong disability.Traditional treatment options such as neurorrhaphy and neurolysis have high failure rates.Surgical reconstruction with autograft carries donor site morbidity and often provide suboptimal results.Mesenchymal stem cells(MSCs)are known to have promising regenerative potential and have gained attention as a treatment option for nerve lesions.It is however,unclear whether it can be effectively used for nerve regeneration.AIM To evaluate the evidence for the use of human umbilical cord derived MSCs(UCMSCs)in peripheral nerve regeneration.METHODS We carried out a systematic literature review in accordance with the PRISMA protocol.A literature search was performed from conception to September 2019 using PubMed,EMBASE and Web of Science.The results of eligible studies were appraised.A risk of bias analysis was carried out using Cochrane’s RoB 2.0 tool.RESULTS Fourteen studies were included in this review.A total of 279 subjects,including both human and animal were treated with UCMSCs.Four studies obtained UCMSCs from a third-party source and the remainder were harvested by the investigators.Out of the 14 studies,thirteen conducted xenogenic transplantation into nerve injury models.All studies reported significant improvement in nerve regeneration in the UCMSC treated groups compared with the various different controls and untreated groups.CONCLUSION The evidence summarised in this PRISMA systematic review of in vivo studies supports the notion that human UCMSC transplantation is an effective treatment option for peripheral nerve injury.

关键词： umbilical cord Mesenchymal stem cells Transplantation Peripheral nerve regeneration

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Child with Wiskott–Aldrich syndrome underwent atypical immune reconstruction after umbilical cord blood transplantation: A case report

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World Journal of Clinical Cases 2019年第21期7卷 3622-3631页

作者： Bo-Han Li Shao-Yan Hu Department of Hematology and Oncology Children’s Hospital of Soochow University

BACKGROUND Timely reconstitution of a donor-derived immune system is important for recovery and long-term survival of patients after allogeneic hematopoietic stem cell transplantation(HSCT).We describe a case of Wiskott–Aldrich syndrome(WAS)treated by umbilical cord blood transplantation(UCBT)with atypical immune reconstruction.CASE SUMMARY A 1-year-old Chinese male infant was diagnosed with WAS.WAS gene sequencing identified the mutation c.777+1G>A(IVS8).On August 8,2017,he was admitted to our hospital for HSCT.We selected an unrelated Human leukocyte antigen 6/10-matched donor for UCBT.After HSCT,the immune reconstitution process was atypical,the lymphocytes reached 0.5×109/L on day 23,and the neutrophils reached 0.5×109/L on day 34.The patient’s recovery throughout the year was good.CONCLUSION An increase in lymphocytes(especially T cells)earlier than granulocytes may be a marker of a good prognosis in UCBT.

关键词： umbilical cord blood transplantation Wiskott-Aldrich syndrome Immune reconstruction Case report

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