The Role of HBx Gene Mutations in PLA2R Positive Hepatitis-B-associated Membranous Nephropathy

作     者：DONG Hui XU Yan XU Ting SUN Jing Yi BU Quan Dong WANG Yan Fei CHE Lin ZHAO Long JIANG Wei DONG Hui;XU Yan;XU Ting;SUN Jing Yi;BU Quan Dong;WANG Yan Fei;CHE Lin;ZHAO Long;JIANG Wei

作者机构：Department of NephrologyThe Affiliated Hospital of Qingdao UniversityQingdao 266003ShandongChina Department of GeratologyThe No.971 Hospital of PLAQingdao 266071ShandongChina 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2020年第33卷第4期

页      面：269-272页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：funded by National Natural Science Foundation of China Qingdao Outstanding Health Professional Development Fund[2020-2022] Chinese Society of Nephrology。 

主　　题：PLA2 diseases membranous 

摘      要：China is a higher-intermediate hepatitis B virus(HBV)endemicity country,and HBV is among the most important infectious diseases[1,2].Hepatitis-Bassociated glomerulonephritis(HBV-GN)is also one of the main forms of secondary kidney diseases seen in China[3].The main pathological type is hepatitis-Bassociated membranous nephropathy(HBV-MN).In the recent years,it has been found that human renal podocyte membrane M-type phospholipase 2 receptor(PLA2R)is the main autoantigen in idiopathic membranous nephropathy(IMN)[4].At present,it is found that PLA2 R and its antibodies are.