Eukaryotic Translation Initiation Factors Shape RNA Viruses Resistance in Plants

作     者：Jannat Shopan Xiaolong Lv Zhongyuan Hu Mingfang Zhang Jinghua Yang Jannat Shopan;Xiaolong Lv;Zhongyuan Hu;Mingfang Zhang;Jinghua Yang

作者机构：Laboratory of Germplasm Innovation and Molecular BreedingInstitute of Vegetable ScienceZhejiang UniversityHangzhou 310058China Key Laboratory of Horticultural Plant Growth and DevelopmentMinistry of Agriculture and Rural AffairsHangzhou 310058China 

出 版 物：《Horticultural Plant Journal》 (园艺学报（英文版）)

年 卷 期：2020年第6卷第2期

页      面：81-88页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 09[农学] 0807[工学-动力工程及工程热物理] 0904[农学-植物保护] 090401[农学-植物病理学] 0901[农学-作物学] 0902[农学-园艺学] 0713[理学-生态学] 

基　　金：The authors thank Mr.Tomas Maher from the Department of Biology at the Pennsylvania State University for language editing.This work is supported by the National Natural Science Foundation of Zhejiang Province(Grant No.LZ20C150002)and the National Natural Science Foundation of China(Grant No.31872095). 

主　　题：eukaryotic translation initiation factor genome editing 3 cap-independent translational enhancer virus resistance 

摘      要：Viruses are representative of a global threat to agricultural production. Genetic resistance is the preferred strategy for the control of viral infection and against loss of crop yield. Viral protein synthesis requires host cellular factors for translating their viral RNAs, and for regulating their replication and cell to cell systemic movement. Therefore, the viruses are dependent on cellular translation factors. Mutations in the gene encoding eIF4E and eIF4G or their isoforms, eIFiso4 E, eIFiso4 G and eIF2Bβ have been mapped as a source of plant potyvirus while other genus of plant virus recessive resistance genes in many species are originated from these loci. Some of other plant translation factors, such as eIF3,eIF4 A-like helicases, eEF1A and eEF1B, which are required in interacting with viral RNAs and regulating various aspects of the infection cycle,have also been identified. Here, we summarized the mechanisms utilized by RNA viruses of eukaryotic plants and the essential roles of e IFs in virus infection. Moreover, we discussed the potential of e IFs as a target gene in the development of genetic resistance to viruses for crop improvement. This review highlighted newly revealed examples of abnormal translational strategies and provided insights into natural host resistance mechanisms that have been linked to 3 cap-independent translational enhancer activity.