Calcium ion as cellular messenger

作     者：ZHENG Jie ZENG XuHui WANG ShiQiang 

作者机构：Department of Physiology and Membrane BiologyUniversity of CaliforniaDavisSchool of Medicine Institute of Life ScienceNanchang University College of Life SciencesPeking University 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2015年第58卷第1期

页      面：1-5页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 

基　　金：NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS072377] Funding Source: NIH RePORTER 

主　　题：钙离子 细胞信使 细胞信号传导 电子信号 化学反应 相互作用 多价离子 动作电位 

摘      要：The prominent role Ca2+ion plays as a major small biological messenger is fascinating.There are many physiologically important ions,such as Na+,K+,H+,Cl?,Ca2+,Mg2+,Fe3+,and PO43?that participate in cell signaling.Among them,monovalent ions primarily contribute to rapid electrical signaling,while multivalent ions generally act as a co-factor for chemical reactions by associating with the host molecule through electrostatic or covalent interactions.Ca2+plays both roles.Its transmembrane influx supports the plateau phase of cardiac action potential and helps set the speed of pacemaker potential.Inside the cell。