Surveys of serum reproductive hormone levels and the prevalence rates of late onset of hypogonadism in Chinese aging males

作     者：周善杰 卢文红 梁小薇 袁冬 李鸿 谷翊群 张宝龙 纪玉党 王灿岗 李宪坤 

作者机构：Department of Male Clinic Research National Research Insti tute for Family Planning Beijing 100081 China Fucheng Technical Service Center of Family Planning Fucheng Hebei 053700China 

出 版 物：《生殖医学杂志》 (Journal of Reproductive Medicine)

年 卷 期：2011年第20卷第B12期

页      面：27-32页

学科分类：090801[农学-水产养殖] 083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 0908[农学-水产] 07[理学] 08[工学] 09[农学] 0903[农学-农业资源与环境] 0713[理学-生态学] 

主　　题：血清生殖激素 激素水平 患病率 中老年 迟发性 男性 性腺 中国 

摘      要：Objective:To investigate the change patterns of reproductive hormones in serum of aging males and the difference among male age brackets and the prevalence rates of late onset of hypogonadism(LOH) in males in Chinese middle and aging males. Methods:Subjects included 1,498 men aged 40 to 69 from a county,and the serum reproductive hormones of 434 subjects were measured and *** addition,the prevalence rates of LOH were analyzed by cut-off point of total testosterone(TT) and free testosterone(cFT),and screening scales(a questionnaire of androgen deficiency in the aging males(ADAM) and a scale of aging males’ symptoms(AMS)).TT,cFT,bio-available testosterone (Bio-T),luteinizing hormone(LH),sex hormone binding globulin(SHBG),testosterone secretion index(TSI), free testosterone index(FTD,the positive rates of LOH screening,androgen deficiency rates and the clinical prevalence rates of LOH were measured or calculated. Results:The serum TT levels did not change significantly with male aging while serum LH and SHBG levels gradually increased,but cFT,Bio-T,TSI and FTI levels gradually decreased with male *** was very significant difference in other six parameters of reproductive hormones(P0.05).There was no correlation between serum TT levels and aging,LH levels(P0.05). However,there was significantly a positive correlation between serum LH,SHBG and age(P0.01),while there were negative correlation between cFT,Bio-T,TSI,FTI and age,LH levels(P0.01).Moreover,SHBG level was positively correlated with LH level(P0.01). Utilizing the Questionnaire of ADAM and AMS to screen subjects aged 40 to 69 years,mean positive rates of LOH screening were 80.77%and 32.34%*** androgen deficiency rates were 14.02%and 43.69% by using TT and cFT cut-off *** addition,mean LOH clinical prevalence rates of subjects on positive questionnaire results were 37.85%and 15.42%. Conclusion:The serum TT levels did