Age-related rhesus macaque models of COVID-19

作     者：Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin Pin Yu;Feifei Qi;Yanfeng Xu;Fengdi Li;Peipei Liu;Jiayi Liu;Linlin Bao;Wei Deng;Hong Gao;Zhiguang Xiang;Chong Xiao;Qi Lv;Shuran Gong;Jiangning Liu;Zhiqi Song;Yajin Qu;Jing Xue;Qiang Wei;Mingya Liu;Guanpeng Wang;Shunyi Wang;Haisheng Yu;Xing Liu;Baoying Huang;Wenling Wang;Li Zhao;Huijuan Wang;Fei Ye;Weimin Zhou;Wei Zhen;Jun Han;Guizhen Wu;Qi Jin;Jianwei Wang;Wenjie Tan;Chuan Qin

作者机构：Key Laboratory of Human Disease Comparative MedicineChinese Ministry of HealthBeijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina MHC Key Laboratory of BiosafetyNational Institute for Viral Disease Control and PreventionChina CDCBeijingChina Department of RadiologyBejing Anzhen HospitalCapital Medical UniversityBeijingChina Institute of Pathogen BiologyChinese Academy of Medical SciencesBeijingChina Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2020年第3卷第1期

页      面：93-97页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 0906[农学-兽医学] 1010[医学-医学技术（可授医学、理学学位）] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0703[理学-化学] 10[医学] 

基　　金：This work was supported by the National Research and Development Project of China(Grant No.2020YFC0841100) Fundamental Research Funds for CAMS of China(Grant No.2020HY320001) National Key Research and Development Project of China(Grant No.2016YFD0500304) CAMS initiative for Innovative Medicine of China(Grant No.2016-I2M-2-006) National Mega projects of China for Major Infectious Diseases(Grant No.2017ZX10304402) and National Key Research and Development Programme of China(2016YFD0500301,2020YFC0840800,2020YFC0840900) 

主　　题：pathogenicity pneumonia rhesus macaque model SARS-CoV-2 

摘      要：Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international *** high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate ***:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune ***:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 *** developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial *** antigens were detected mainly in alveolar epithelial cells and ***:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young *** macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection.