Preoperative gamma-glutamyltransferase to lymphocyte ratio predicts long-term outcomes in intrahepatic cholangiocarcinoma patients following hepatic resection

作     者：Jin-Ju Wang Hui Li Jia-Xin Li Lin Xu Hong Wu Yong Zeng 

作者机构：Department of Liver Surgery and Liver Transplantation CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Laboratory of Liver SurgeryWest China HospitalSichuan UniversityChengdu 610065Sichuan ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第13期

页      面：1501-1512页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the National Key Technologies RD Program,No.2018YFC1106803 the Natural Science Foundation of China,No.81972747,No.81872004,No.81770615 and No.81672882 the Science and Technology Support Program of Sichuan Province,No.2019YFQ0001 and No.2017SZ0003 

主　　题：Gamma-glutamyltransferase Lymphocyte ratio Gamma-glutamyltransferase to lymphocyte ratio Intrahepatic cholangiocarcinoma Prognosis Survival analysis 

摘      要：BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a heterogeneous hepatobiliary cancer with limited treatment options.A number of studies have illuminated the relationship between inflammation-based prognostic scores and outcomes in patients with ***,the use of reliable and personalized prognostic algorithms in ICC after resection is *** To assess the prognostic value of the gamma-glutamyltransferase to lymphocyte ratio(GLR)in ICC patients following curative *** ICC patients following curative resection(2009-2017)were divided into two cohorts:The derivation cohort and validation *** derivation cohort was used to explore an optimal cut-off value,and the validation cohort was used to further evaluate the *** survival(OS)and recurrence-free survival(RFS)were analyzed,and predictors of OS and RFS were *** A total of 527 ICC patients were included and randomly divided into the derivation cohort(264 patients)and the validation cohort(263 patients).The two patient cohorts had comparable baseline *** optimal cut-off value for the GLR was ***-Meier curves showed worse OS and RFS in the GLR33.7 group compared with GLR≤33.7 group in both *** univariate and multivariate analysis,the results indicated that GLR was an independent prognostic factor of OS[derivation cohort:hazard ratio(HR)=1.620,95%confidence interval(CI):1.066-2.462,P=0.024;validation cohort:HR=1.466,95%CI:1.033-2.142,P=0.048]and RFS[derivation cohort:HR=1.471,95%CI:1.029-2.103,P=0.034;validation cohort:HR=1.480,95%CI:1.057-2.070,P=0.022].CONCLUSION The preoperative GLR is an independent prognostic factor for ICC patients following hepatectomy.A high preoperative GLR is associated with worse OS and RFS.