肝移植术后预防性使用熊去氧胆酸对原发性胆源性胆管炎的长期影响

作     者：Corpechot C Chazouillères O Belnou P 戴清清(摘译) 赵义军(审校) Corpechot C;Chazouillères O;Belnou P

作者机构：Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis ERN Rare-Liver Saint-Antoine Hospital Assistance Publique - Hôpitaux de Paris Inserm UMR_S938 Saint-Antoine Research Center Sorbonne University Paris France Public Health Unit Saint-Antoine Hospital Assistance Publique–Hôpitaux de Paris Pierre Louis Institute of Epidemiology and Public Health Sorbonne University Paris France Division of Gastroenterology and Liver Unit University of Alberta Edmonton Canada Department of General Visceral and Transplantation Surgery Charité University Hospital Berlin Germany Department of Medicine I and Martin Zeitz Center for Rare Diseases University Medical Center Hamburg–Eppendorf Hamburg Germany Department of Medicine III University Hospital RWTH Aachen Aachen Germany Department of Internal Medicine IV Integrated Research and Treatment Center for Sepsis Control and Care University Hospital Jena Germany Department of General Visceral and Vascular Surgery University Hospital Jena Jena Germany University College London Institute for Liver and Digestive Health Royal Free Hospital London United Kingdom National Institute for Health Research Centre for Liver Research University Hospitals Birmingham Institute of Immunology and Immunotherapy University of Birmingham United Kingdom National Institute for Health Research Centre for Liver Research University Hospitals Birmingham Institute of Immunology and Immunotherapy University of Birmingham United Kingdom Department of Gastroenterology University Hospitals Birmingham National Health Service Foundation Trust Queen Elizabeth Hospital Birmingham United Kingdom Toronto Centre for Liver Disease University Health Network University of Toronto Toronto Canada Department of Gastroenterology University Hospitals Birmingham National Health Service Foundation Trust Queen Elizabeth Hospital Birmingham United Kingdom Division Liver and Biliopancreatic Disorders University Hospitals KU Leuven Belgium Transplant Hepatology Unit Edouard Herriot Hospital Hospices Civils de Lyon Claude Bernard University Lyon France Transplant Hepatology Unit Croix Rousse Hospital Hospices Civils de Lyon Claude Bernard University Lyon France Hepatology and Gastroenterology Department Geneva University Hospitals Geneva Switzerland Transplant Hepatology Unit Pitié-Salpêtrière Hospital Assistance Publique–Hôpitaux de Paris Sorbonne University Paris France Liver Unit Hospital Clínic University of Barcelona The August Pi i Sunyer Biomedical Research Institute Biomedical Research Networking Center in Hepatic and Digestive Diseases Barcelona Spain Transplant Hepatology Unit Division of Gastroenterology and Hepatology Maggiore Hospital Policlinico Milan Italy Department of Surgery Oncology and Gastroenterology University of Padova Padova Italy Department of Gastroenterology and Hepatology Ghent University Hospital Ghent Belgium Department of Gastroenterology and Hepatology Erasmus University Medical Center Rotterdam The Netherlands Department of Gastroenterology and Hepatology Erasmus University Medical Center Rotterdam The Netherlands Toronto Centre for Liver Disease University Health Network University of Toronto Toronto Canada 

出 版 物：《肝胆外科杂志》 (Journal of Hepatobiliary Surgery)

年 卷 期：2020年第28卷第1期

页      面：72-72页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Falk Pharma Intercept France Intercept Pharmaceuticals Inventiva Pharma and Genkyotex University Hospitals KU GlaxoSmithKline, GSK Boston Scientific Corporation, BSC Merz Pharmaceuticals 

主　　题：预防性使用 肝移植术后 胆管炎 回顾性队列研究 胆源性 移植物 熊去氧胆酸 UDCA 

摘      要：背景与目的肝移植术后原发性胆源性胆管炎(PBC)的复发很常见并且会损害移植物以及影响患者的存活。熊去氧胆酸(UDCA)是目前治疗PBC的标准药物。本研究旨在探究肝移植术后预防性使用UDCA对PBC的复发率和长期预后的影响。方法本研究为回顾性队列研究,研究对象包括1983年至2017年间在16个中心和9个国家接受肝移植术的780例PBC患者,中位随访时间为11年。其中,有190位患者术后预防性使用UDCA (10~15mg/kg/d)治疗。主要结局为经组织学证实的PBC复发,次要结局为移植物丢失、肝脏相关死亡和各种原因死亡。