Bioactive polymeric materials and electrical stimulation strategies for musculoskeletal tissue repair and regeneration

作     者：Bryan Ferrigno Rosalie Bordett Nithyadevi Duraisamy Joshua Moskow Michael R.Arul Swetha Rudraiah Syam P.Nukavarapu Anthony T.Vella Sangamesh G.Kumbar 

作者机构：Department of Orthopedic SurgeryUniversity of Connecticut HealthFarmingtonCTUSA Department of Biomedical EngineeringUniversity of ConnecticutStorrsCTUSA Department of Pharmaceutical SciencesUniversity of Saint JosephHartfordCTUSA Department of Department of ImmunologyUniversity of Connecticut HealthFarmingtonCTUSA 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2020年第5卷第3期

页      面：468-485页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：support from the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health(R01EB020640) the Connecticut Regenerative Medicine Research Fund(15-RMBUCHC-08) 

主　　题：Electrical stimulation Conductive polymers Ionic conductivity Tissue engineering Muscle Tendon Ligament Nerve Bone and wound healing 

摘      要：Electrical stimulation(ES)is predominantly used as a physical therapy modality to promote tissue healing and functional *** efforts in both laboratory and clinical settings have shown the beneficial effects of this technique for the repair and regeneration of damaged tissues,which include muscle,bone,skin,nerve,tendons,and *** collective findings of these studies suggest ES enhances cell proliferation,extracellular matrix(ECM)production,secretion of several cytokines,and vasculature development leading to better tissue regeneration in multiple ***,there is still a gap in the clinical relevance for ES to better repair tissue interfaces,as ES applied clinically is ineffective on deeper *** use of a conducting material can transmit the stimulation applied from skin electrodes to the desired tissue and lead to an increased function on the repair of that *** conductive(IC)polymeric scaffolds in conjunction with ES may provide solutions to utilize this approach *** IC formulations and their scaffolds may provide solutions for applying ES into difficult to reach tissue types to enable tissue repair and regeneration.A better understanding of ES-mediated cell differentiation and associated molecular mechanisms including the immune response will allow standardization of procedures applicable for the next generation of regenerative ***,along with the use of IC scaffolds is more than sufficient for use as a treatment option for single tissue healing and may fulfill a role in interfacing multiple tissue types during the repair process.