Correlation of Lower Concentrations of Hydrogen Sulfide with Activation of Protein Kinase CIVIl in Uremic Accelerated Atherosclerosis Patients

作     者：Wei Wang Su-Juan Feng Han Li Xiao-Dong Zhang Shi-Xiang Wang Wang Wei;Feng Su-Juan;Li Han;Zhang Xiao-Dong;Wang Shi-Xiang

作者机构：Institute of Uro-Nephrology Beijing Chao-Yang Hospital Capital Medical University Beijng 100020 China Department of Blood Purification Beijing Chao-Yang Hospital Capital Medical University Nephrology Faculty Capital Medical University Beijng 100020 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2015年第128卷第11期

页      面：1465-1470页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：This work was supported by grants from National Natural Science Foundation of China (No. 81200543)  Beijing Natural Science Foundation (No. 7142057)  Beijing Municipal Health Bureau High-level Medical Professionals Promotion Project (No. 2013-3-016) and Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (No. ZYLX201408) 

主　　题：Hemodialysis Hydrogen Sulfide Protein Kinase Cβ11 Uremic Accelerated Atherosclerosis 

摘      要：Background： Hydrogen sulfide （H,S） plays a protective role in chronic hemodialysis （CHD） patients. In this study, we further investigate the relationship between H,S and conventional protein kinase CβII （cPKCβII） in CHD patients with uremic accelerated atherosclerosis （UAAS）. Methods： A total of 30 healthy people, 30 CHD patients without AS and 30 CHD patients with AS （CHD ＋ AS） were studied. Plasma H,S was measured with a sulfide sensitive electrode, and cPKCβ11 membrane translocation was detected by Western blotting. Results： Plasma H2S in CHD ＋ AS group was significantly lower than that in CHD patients, cPKCβII membrane translocation in CHD ＋AS group increased significantly compared with CHD group. Plasma H,S concentration was negatively correlated with cPKCβ11 membrane translocation in CHD ＋ AS patients. Conclusions： These findings suggest a possible linkage between H,S metabolism and cPKCβ11 activation, which may contribute to the development of UAAS in CHD patients.