An iridium(Ⅲ)-palladium(Ⅱ) metal-organic cage for efficient mitochondria-targeted photodynamic therapy

作     者：Chaojie Li Yaping Wang Yulin Lu Jing Guo Chengyi Zhu Haozhe He Xiaohui Duan Mei Pan Chengyong Su Chaojie Li;Yaping Wang;Yulin Lu;Jing Guo;Chengyi Zhu;Haozhe He;Xiaohui Duan;Mei Pan;Chengyong Su

作者机构：MOE Laboratory of Bioinorganic and Synthetic ChemistryLehn Institute of Functional MaterialsSchool of ChemistrySun Yat-Sen UniversityGuangzhou 510275China School of Materials Science and Engineering and School of ChemistrySun Yat-Sen University.Guangzhou 510275China Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2020年第31卷第5期

页      面：1183-1187页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 0703[理学-化学] 10[医学] 

基　　金：supported by the National Natrual Science Foundation of China(NSFC,Nos.21771197,21720102007,21821003) Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(No.2017BT01C161) FRF for the central universities。 

主　　题：Metal-organic cage Photodynamic therapy Mitochondria-targeted Ir(Ⅲ)metalloligand Two-photon 

摘      要：An Ir8 Pd4-heteronuclear metal-organic cage(MOC-51)was assembled from bipodal metalloligand[Ir(ppy)2(qpy)(BF4)](qpy=4,4′:2′,2″:4″,4′′′-quaterpyridine;ppy-2-phenylpridine)with Pd(Ⅱ)salt.The cubic barrel shaped MOC shows one-photon and two-photon excited deep-red emission,as well as large singlet oxygen quantum yields under visible light irradiation,therefore exhibiting great potentials in organelles-targeted cell imaging and photodynamic therapy(PDT).Compared with the Ir(Ⅲ)metalloligand,the Ir8 Pd4-MOC showed less dark toxicity and higher mitochondria-targeting efficiency.The localization in mitochondria overco mes the limitation of short lifetime and diffusion distance of ROS in cell,thus improved PDT effect can be obtained in low light dose usage of the MOC.This study presents the first case of Ir-based metal-organic cages for bio-applications in successful integration of imaging diagnosis and photodynamic therapy.