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An iridium(Ⅲ)-palladium(Ⅱ) metal-organic cage for efficient Mitochondria-targeted photodynamic therapy

Chinese Chemical Letters 2020年第5期31卷 1183-1187页

作者： Chaojie Li Yaping Wang Yulin Lu Jing Guo Chengyi Zhu Haozhe He Xiaohui Duan Mei Pan Chengyong Su MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-Sen UniversityGuangzhou 510275China School of Materials Science and Engineering and School of Chemistry Sun Yat-Sen University.Guangzhou 510275China Sun Yat-Sen Memorial Hospital Sun Yat-Sen UniversityGuangzhou 510120China

An Ir8 Pd4-heteronuclear metal-organic cage(MOC-51)was assembled from bipodal metalloligand[Ir(ppy)2(qpy)(BF4)](qpy=4,4′:2′,2″:4″,4′′′-quaterpyridine;ppy-2-phenylpridine)with Pd(Ⅱ)salt.The cubic barrel shaped MOC shows one-photon and two-photon excited deep-red emission,as well as large singlet oxygen quantum yields under visible light irradiation,therefore exhibiting great potentials in organelles-targeted cell imaging and photodynamic therapy(PDT).Compared with the Ir(Ⅲ)metalloligand,the Ir8 Pd4-MOC showed less dark toxicity and higher mitochondria-targeting efficiency.The localization in mitochondria overco mes the limitation of short lifetime and diffusion distance of ROS in cell,thus improved PDT effect can be obtained in low light dose usage of the MOC.This study presents the first case of Ir-based metal-organic cages for bio-applications in successful integration of imaging diagnosis and photodynamic therapy.

关键词： Metal-organic cage Photodynamic therapy Mitochondria-targeted Ir(Ⅲ)metalloligand Two-photon

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A Mitochondria-targeted fluorescent probe for ratiometric detection of hypochlorite in living cells

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Chinese Chemical Letters 2017年第10期28卷 1957-1960页

作者： Yahui Chen Tingwen Wei Zhijie Zhang Wei Zhang Jing Lv Tiantian Chen Bo Chi Fang Wang Xiaoqiang Chen State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University Nanjing 210009 China College of Food Science and Light Industry Nanjing Tech University Nanjing 211816 China

Hypochlorous acid（HOCl） plays a vital role in many physiological and pathological processes as one of reactive oxygen species（ROS）. Developing highly sensitive and selective methods for HOCl detection is of significant interest. In this work, we developed a benzothiazole based probe 1 for ratiometric fluorescence detection of hypochlorite in living cells. The probe can detect HOCl with high selectivity, fast response（within 30 s） as well as low detection limit（0.18 mmol/L）. Fluorescence co-localization studies demonstrated that probe 1 was a Mitochondria-targeted fluorescent probe. Furthermore, confocal fluorescence images of He La cell indicated that probe 1 could be used for monitoring intracellular HOCl in living cells. Finally, test strips experiment suggests that the probe 1 can detect the hypochlorous acid in tap water accompanied by remarkable color change.

关键词： Fluorescent probe Mitochondria-targeted Ratiometric detection Hypochlorous acid ROS

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Liposome trade-off strategy in Mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced antitumor phototherapy in vivo

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Nano Research 2021年第7期14卷 2432-2440页

作者： Xianghan Zhang Sumei Zhao Zhiqing Gao Jialin Zhou Yuqiong Xia Jie Tian Changhong Shi Zhongliang Wang Engineering Research Center of Molecular&Neuroimaging Ministry of EducationSchool of Life Science and TechnologyXidian UniversityXi’an 710026China Key Laboratory of Molecular Imaging Institute of AutomationChinese Academy of SciencesBeijing 100190China Laboratory Animal Center Fourth Military Medical UniversityXi’an 710032China

Cancer phototheranostics involving optical imaging-guided photodynamic therapy(PDT)and photothermal therapy(PTT)is a localized noninvasive approach in treating cancer.Mitochondria-targeted near-infrared(NIR)cyanines are excellent therapeutic photosensitizers of cancer.However,most Mitochondria-targeted cyanines exist in the form of hydrophobic structures,which in vivo may cause cyanine aggregation during blood circulation,resulting in poor biocompatibility and limited therapeutic efficacy.Therefore,we developed a trade-off strategy by encapsulating Mitochondria-targeted cyanines into liposomal bilayers(CyBI7-LPs),which balanced hydrophilicity that favored blood circulation and hydrophobicity that enhanced mitochondria tumor targeting.Moreover,CyBI7-LPs greatly minimized photobleaching of cyanine as self-generated reactive oxygen species(ROS)could rapidly escape from the liposomal bilayer,affording enhanced PTT/PDT efficacy.Bioorthogonal-mediated targeting strategy was further employed to improve uptake of tumor cells by modifying the liposomal surface to generate CyBI7-LPB.The CyBI7-LPB probe produced a tumor-to-background ratio(TBR)of approximately 6.4 at 24 HPI.Guiding by highly sensitive imaging resulted in excellent anti-tumor therapy outcomes using CyBI7-LPB due to the enhanced photothermal and photodynamic effects.This proposed liposomal nanoplatform exhibited a simple and robust approach as an imaging-guided synergistic anti-tumor therapeutic strategy.

关键词： cancer phototheranostics NIR cyanine liposome Mitochondria-targeted phototherapy

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Mitochondria-targeted Ir@AuNRs as bifunctional therapeutic agents for hypoxia imaging and photothermal therapy

Mitochondria-targeted Ir@AuNRs as bifunctional therapeutic a...

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第十一届全国化学生物学学术会议

作者： Libing Ke Cheng Zhang Xinxing Liao Kangqiang Qiu Thomas W.Rees Yu Chen Zizhuo Zhao LiangNian Ji Hui Chao MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-Sen University

Theranostic nanoagents are in great demand to meet the request of precision medicine. Herein, taken the advantage of Ir（III） complex and gold nanorod, bifunctional theranostic nano-agent, Ir@AuNRs, was developed[1]. Aimed at the over-expression azoreductase under hypoxic condition[2], Ir（III） complex employing azo-based turn-on fluorescent to images hypoxic level was synthesized and coated onto the surface of gold nanorod. The feasibility of dragging gold nanorod into mitochondria by Ir（III） complex was proved by ICP-MS, bio-TEM and co-staining experiment. The improvement of photothermal therapy efficiency and reduction of side effects was achieved, which was resulted from the specific mitochondria-targeting of Ir@AuNRs. The ability of Ir@AuNRs for hypoxia imaging and photothermal therapy were demonstrated in vitro and in vivo.

关键词： Ir complex Mitochondria-targeted hypoxia imaging therapeutic agents

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Heterobifunctional PEG-modified Black Phosphorus Quantum Dots:“Three-in-One” Nanoplatforms for Mitochondria-targeted Photothermal Cancer Therapy

Heterobifunctional PEG-modified Black Phosphorus Quantum Dot...

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第十一届全国化学生物学学术会议

作者： Junyang Qi Yue Xiong Ke Cheng Qi Huang Jingxiu Cao Fumei He Gan Liu Wenbin Deng School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen University

Mitochondria-targeted black phosphorus(BP) nanomaterials are expected to achieve enhanced photothermal antitumor effects since mitochondria are more sensitive to hyperthermia and BP excellent optical properties.However,there are several challenges to overcome before offering real benefits,such as poor stability,poor dispersibility,and difficulty in achieving a real mitochondria targeting.Here,a "three-in-one" Mitochondria-targeted BP nanoplatform,called as BPQD-PEG-TPP,was designed.In this nanoplatform,BP quantum dots(BPQDs) were covalently modified with a heterobifunctional PEG,in which one end was an aryl diazo group capable of reacting with BPQDs to form a covalent bond and the other end was a Mitochondria-targeted triphenylphosphine(TPP) group.Besides of its excellent near-infrared photothermal properties,BPQD-PEG-TPP had good dispersibility and much enhanced stability under physiological conditions,efficiently targeted mitochondria and promoted ROS production through a photothermal effect.The combination of targeting mitochondria and PTT resulted in an excellent ability to inhibit tumor cell growth both in vitro and in vivo.Thus this "three-in-one" BP nanoplatform with enhanced photothermal efficacy and negligible toxicity on healthy tissues might be a promising strategy for Mitochondria-targeted photothermal cancer therapy.

关键词： Mitochondria-targeted Black phosphorus quantum dots Photothermal therapy

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Mitochondria-targeted metalloporphyrin for magnetic resonance imaging-guided photodynamic therapy

Mitochondria-targeted metalloporphyrin for magnetic resonanc...

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中国化学会第五届卟啉与酞菁学术研讨会

作者： Mengqian Yang Fengshou Wu School of Chemical Engineering ＆ Pharmacy Wuhan Institute of Technology

Photodynamic therapy（PDT）,as a minimally invasive and high-efficiency anticancer approach,has received extensive research attention recently.Magnetic resonance imaging（MRI） plays a key role in cancer detection and therapeutic monitoring.Porphyrin derivatives have been widely applied in MR imaging and photodynamic cancer therapy[1].However,the search for more effective,lower toxicity,and higher specificity photodynamic photosensitizers with good biocompatibility are still highly expected.Herein,we designed and synthesized a multifunctional porphyrin-based photosensitizer MnPtPor-PPh3 that integrates MRI and fluorescence diagnostics and mitochondrial-targeted photodynamic therapy（Fig.1）.Specifically,the manganese porphyrin coordinated with transplatin exhibits high synergetic chemo-photodynamic antitumor effect and excellent magnetic resonance imaging performance due to the planar structure of porphyrin,which allows the water molecules to fully contact the paramagnetic metal manganese.A lipophilic triphenylphosphonium cation（TPP） as a good Mitochondria-targeted agent was further conjugated to MnPtPor through an alkyl chain to achieve good organelle-targeted property.Thus,the as-synthesized MnPtPor-PPh3 showed synergetic antitumor effect and excellent MR imaging performance,which provided a feasible synthetic strategy to develop new medicines for MRI-guided and organelle-targeted PDT applications in cancer theranostic.

关键词： photodynamic therapy magnetic resonance imaging porphyrin Mitochondria-targeted

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线粒体靶向的SO2比率荧光探针的构建及细胞成像研究

线粒体靶向的SO2比率荧光探针的构建及细胞成像研究

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中国化学会第30届学术年会

作者：曾林涛徐俊超潘健江晓明天津理工大学化学化工学院

本文通过苯并吲哚季铵盐与咔唑醛缩合制备了一种红色荧光的新型荧光探针。该荧光探针可以与HSO发生专一性地亲核加成反应来破坏分子内的共轭双键,导致探针溶液的颜色由红色变为无色,荧光由红色变为蓝色。该荧光探针具有水溶性好、与HSO... 详细信息

本文通过苯并吲哚季铵盐与咔唑醛缩合制备了一种红色荧光的新型荧光探针。该荧光探针可以与HSO发生专一性地亲核加成反应来破坏分子内的共轭双键,导致探针溶液的颜色由红色变为无色,荧光由红色变为蓝色。该荧光探针具有水溶性好、与HSO定量反应、响应时间短、专一性强、检测限低(10 nM)等优点。细胞成像实验表明该探针具有良好的线粒体靶向性和细胞渗透性,能够用于活细胞中内源性及外源性SO衍生物的实时在线检测,表现出良好的比率荧光信号。

关键词： Fluorescent probe SO2 derivatives Benzo[e]indolium Mitochondria-targeted Imaging

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