Fructose as a key player in the development of fatty liver disease

作     者：Metin Basaranoglu Gokcen Basaranoglu Tevfik Sabuncu Hakan Sentürk 

作者机构：Department of Gastroenterology and HepatologyBezmialem Vakif UniversityIstanbul 34400Turkey Department of AnaesthesiologyBezmialem Vakif UniversityIstanbul 34400Turkey Department of EndocrinologyHarran UniversitySanliurfa 68000Turkey 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第8期

页      面：1166-1172页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Nonalcoholic Fatty liver Diabetes Insulin resistance Cytokines Obesity Fructose 

摘      要：We aimed to investigate whether increased consumption of fructose is linked to the increased prevalence of fatty *** prevalence of nonalcoholic steatohepatitis(NASH) is 3% and 20% in nonobese and obese subjects,*** is a low-grade chronic inflam-m-atory condition and obesity-related cytokines such as interleukin-6,adiponectin,leptin,and tumor necrosis factor-α may play important roles in the developm-ent of nonalcoholic fatty liver disease(NAFLD).Additionally,the prevalence of NASH associated with both cirrhosis and hepatocellular carcinom-a was reported to be high am-ong patients with type 2 diabetes with or without *** research group previously showed that consumption of fructose is associated with adverse alterations of plasma lipid profiles and metabolic changes in m-ice,the Am-erican Lifestyle-Induced Obesity Syndrom-e m-odel,which included consum-ption of a high-fructose corn syrup in amounts relevant to that consum-ed by som-e *** observation reinforces the concerns about the role of fructose in the obesity *** availability of fructose(e.g.,high-fructose corn syrup) increases not only abnorm-al glucose flux but also fructose m-etabolism-in the ***,the anatomic position of the liver places it in a strategic buffering position for absorbed carbohydrates and am-ino *** was previously accepted as a beneficial dietary com-ponent because it does not stim-ulate insulin ***,since insulin signaling plays an important role in central m-echanism-s of NAFLD,this property of fructose m-ay be *** has a selective hepatic m-etabolism,and provokes a hepatic stress response involving activation of c-Jun N-term-inal kinases and subsequent reduced hepatic insulin *** high fat diet alone produces obesity,insulin resistance,and som-e degree of fatty liver with m-inim-al inflam-m-ation and no fibrosis,the fast food diet which includes fructose and fats produces a