T8 神经药理学

出 版 物：《中国药理学与毒理学杂志》 (Chinese Journal of Pharmacology and Toxicology)

年 卷 期：2019年第33卷第10期

页      面：841-879页

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：神经药理学 cerebral MCAO artery 

摘      要：Effect of active components group of Xiaoxuming decoction on cerebral mitophagy after focal cerebral ischemia/reperfusion injury,OBJECTIVE To explore the effect of the active components group of Xiaoxuming decoction(XXMD)on mitophagy after cerebral ischemia/reperfusion(I/R)in MCAO rats.METHODS Male Sprague-Dawley rats were randomly divided into 4 groups:sham group,XXMD and rapamycin group.The I/R models were induced by middle cerebral artery occlusion.The effects of XXMD and rapamycin on behavioral study of focal cerebral I/R in rats were measured by Zea-Longa′s level standard scoring method and neurological defect score(m NSS).