The role of cofilin in age-related neuroinflammation
The role of cofilin in age-related neuroinflammation作者机构：Department of Medicinal and Biological Chemistry College of Pharmacy and Pharmaceutical Sciences University of Toledo
出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)
年 卷 期：2020年第15卷第8期
页 面：1451-1459页
核心收录：
学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）]
基 金：supported by Fellowship from Saudi Arabia Cultural Mission College of Pharmacy Department of Pharmaceutical Chemistry King Saud University Riyadh Saudi Arabia
主 题：aging astrocyte-activation cofilin cofilin inhibitor cofilin/actin rods inflammaging microglial activation neurogenesis neuroinflammation
摘 要：Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active“pro-inflammatorystate,causing chronic low-grade *** the fact that the role of neuroinflammation during aging has been extensively studied in recent years,the underlying causes remain *** identification of relevant proteins and understanding their potential roles in neuroinflammation can help explain their potential of becoming biomarkers in the aging brain and as drug targets for prevention and *** will eventually reduce the chances of developing neurodegenerative diseases and promote healthier lives in the *** this review,we have summarized the morphological and cellular changes in the aging brain,the effects of age-related neuroinflammation,and the potential role of cofilin-1 during *** also discuss other factors contributing to brain aging and neuroinflammation.
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