Ouabain inhibits anchorage-independent growth in human lung cancer cells via integrinαvβ3 reduction

作     者：Chuanpit Ninsontia Varisa Pongrakhananon Chatchai Chaotham Pithi Chanvorachote 

作者机构：Cell-based Drug and Health Products Development Research Unit Faculty of Pharmaceutical SciencesChulalongkorn University 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2016年第11卷第1期

页      面：189-190页

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Chulalongkorn University, CU, (CU-56-384-HR) Thailand Research Fund, TRF, (PHD/0004/2556) 

主　　题：Ouabain Anchorage-independent growth Lung cancer cells Integrinαvβ3 reduction 

摘      要：Physiological effects of ouabain (Fig. 1A), a human endogenous hormone, have been intensively investigated *** studies demonstrate anticancer activity of ouabain in sensitization of apoptosis and suppression of migration in lung cancer cells (1,2)Focusing on metastatic process, the ability of cancer cells to grow in an anchorage-independent condition determines the success of cancer metastasis [3].