Intracellular behaviour of samarium and europium in lactating mammary gland

作     者：Ayadi Ahlem Maghraoui Samira El Hili Ali Galle Pierre Tekaya Leila 

作者机构：Laboratoire de physiologie Faculté de Médecine de Tunis. 15 rue Djebel lakhdhar. 1007 La Rabta. Tunis. Université Tunis El Manar Tunisie Laboratoire de microscopie électronique Faculté des Sciences de Tunis Campus universitaire 2092 El Manar II Tunis Université Tunis El Manar Tunisie. Université Tunis El Manar Tunisie Universidade Estdual de Santa Cruz CNPq rod. Ilheus-Itabuna Km. 16 Ilheus Ba. Brasil 

出 版 物：《Journal of Rare Earths》 (稀土学报（英文版）)

年 卷 期：2012年第30卷第3期

页      面：274-277页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

主　　题：samarium europium transmission electron microscopy (TEM) lysosome mammary gland lactation rare earths 

摘      要：The subcellular localization of samarium and europium, two rare-earths, increasingly used in both medical and industrial fields, has been studied in several organs such as liver and kidney but never in the mammary gland despite of its importance in the biology of lactation and nutrition domains. The intracellular behaviour of samarium and europium after their intra-peritoneal administration in the lactating mammary gland cells was investigated. The results showed the presence of very electron dense deposits in the glandular epithelial cell lysosomes. These particular lysosomes were never observed in the mammary cell lysosomes of control rats. These intralysosomal deposits were probably composed of insoluble samarium or europium phosphates by analogy with previous studies, the transmission electron microscopy, the ion mass microscopy and the electron probe microanalysis, and other techniques allowing the identification of the chemical structure of the intralysosomal deposits.