NAD＋ and its precursors in human longevity

作     者：Jimin Lin Yanchao Pan Jiangyun Wang 

作者机构：Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR 999077 China 

出 版 物：《Frontiers of Electrical and Electronic Engineering in China》 (中国电气与电子工程前沿（英文版）)

年 卷 期：2015年第10卷第4期

页      面：193-198页

核心收录：

学科分类：0710[理学-生物学] 12[管理学] 1204[管理学-公共管理] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：We gratefully acknowledge the National Natural Science Foundation of China (No. 21502026)  Shenzhen Science and Technology Innovation Committee (JCYJ20140411112047887) for their support to Yanchao Pan. We thank Dr. Zhen Xie for comments on the manuscript 

主　　题：longevity sirtuins NAD+ NAD+ synthesis NAD+ precursor nicotinamide riboside 

摘      要：Aging is a complex issue due to its nature in progressive physiological and functional decay. As better medicine, technology, and living conditions became accessible to many people, the longevity of human beings increased during the past centuries. Recent research established vital roles for NAD＋ and its precursors in protecting and maintaining the redox homeostasis in cells, which might be applicable therapeutically to prevent cell degeneration. Notably, the contribution of NAD＋ metabolites to lifespan extension in model systems indicates that the potential beneficial effects of NAD＋ precursors. In this mini review, by introducing the background of NAD＋-consuming enzymes in ＂caloric restriction＂, we focus on NAD＋ and its precursors in diet, with further emphasis on its association with health and diseases. We also provide insights in future utilization ofNAD＋ and its precursors as nutrition supplement for lifespan extension.