HBV endemicity in Mexico is associated with HBV genotypes H and G

作     者：Sonia Roman Arturo Panduro 

作者机构：Department of Molecular Biology in MedicineCivil Hospital of Guadalajara"Fray Antonio Alcalde"and Health Sciences CenterUniversity of Guadalajara 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第33期

页      面：5446-5453页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by National Council of Science and Technology(CONACYT-FONDO SECTORIAL Mexico) Grant No.Salud-2010-1-139085 to Roman S Jalisco State Council of Science and Technology(COECYTJAL-Universidad de Guadalajara Guadalajara Jalisco Mexico) Grant No.2009-1-06-2009-431 to Panduro A 

主　　题：Hepatitis B virus genotypes Hepatitis B virus genotype H Hepatitis B virus genotype G Molecular epidemiology Mexico Antiviral therapy Severity of liver disease Clinical outcome 

摘      要：Hepatitis B virus(HBV)genotypes have distinct genetic and geographic diversity and may be associated with specific clinical characteristics,progression,severity of disease and antiviral ***,we provide an updated overview of the endemicity of HBV genotypes H and G in *** genotype H is predominant among the Mexican population,but not in Central *** geographic distribution is related to a typical endemicity among the Mexicans which is characterized by a low hepatitis B surface antigen seroprevalence,apparently due to a rapid resolution of the infection,low viral loads and a high prevalence of occult B *** chronic infections,genotype H is detected in mixtures with other HBV genotypes and associated with other co-morbidities,such as obesity,alcoholism and co-infection with hepatitis C virus or human immunodeficiency *** carcinoma prevalence is ***,antiviral therapy may differ significantly from the standard guidelines established *** high prevalence of HBV genotype G in the Americas,especially among the Mexican population,raises new questions regarding its geographic origin that will require further investigation.