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Renal sympathetic denervation in resistant hypertension

Renal sympathetic denervation in resistant hypertension

作     者:Mário Santos Henrique Carvalho 

作者机构:Cardiology DepartmentHospital Santo AntónioLargo Professor Abel Salazar4099-001 PortoPortugal 

出 版 物:《World Journal of Cardiology》 (世界心脏病学杂志(英文版)(电子版))

年 卷 期:2013年第5卷第4期

页      面:94-101页

学科分类:1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主  题:Arterial hypertension Sympathetic activity Renal denervation Percutaneous ablation Resistant hypertension 

摘      要:Resistant hypertension remains a major clinical problem despite the available multidrug *** the next decades,its incidence will likely increase given that it is strongly associated with older age and *** hypertension patients have an increased cardiovascular risk,thus effective antihypertensive treatment will provide substantial health *** crosstalk between sympathetic nervous system and kidneys plays a crucial role in *** influences several pathophysiological mechanisms such as the central sympathetic tone,the sodium balance and the systemic neurohumoral *** fact,studies using several animal models demonstrated that the renal denervation prevented and attenuated hypertension in multiple *** reductions in blood pressure were also observed in malignant hypertension patients submitted to sympathectomy ***,these approaches had an unacceptably high rates of periprocedural complications and disabling adverse ***,an innovative non-pharmacological therapy that modulates sympathetic activation has been successfully *** sympathetic percutaneous denervation is an endovascular procedure that uses radiofrequency energy to destroy the autonomic renal nerves running inside the adventitia of renal *** method represents a promising new approach to the strategy of inhibiting the sympathetic nervous *** aim of this review is to examine the background knowledge that resulted in the development of this hypertension treatment and to critically appraise the available clinical evidence.

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