The diagnostic accuracy of the usage of the <i>Fetal Medicine Foundation</i>’s (FMF) on-line risk calculator with first-trimester ultrasound for screening for preeclampsia in high-risk pregnant Brazilian population

作     者：Ernesto Antonio Figueiró-Filho Maithe Vendas Galhardo Bruno Areco de Souza 

作者机构：Faculty of Medicine University Hospital Federal University of Mato Grosso do Sul Campo Grande Brazil 

出 版 物：《Open Journal of Obstetrics and Gynecology》 (妇产科期刊（英文）)

年 卷 期：2012年第2卷第3期

页      面：298-303页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Accuracy Sensitivity Specificity Preeclampsia First Trimester Risk 

摘      要：To evaluate the sensitivity and specificity of the usage of the FMF On-Line Risk Calculator with first-trimester ultrasound, in screening assessment for preeclampsia (PE), without serum markers. To define the best risk cut-off values for early, intermediate and late preeclampsia. Diagnostic accuracy study of pregnant women who had first-trimester ultrasounds between 11 and 13 weeks. The index test was the first-trimester ultrasound scan plus the FMF On-Line Risk Calculator to assess the risk for PE. The reference standard was the confirmation of actual development of early, intermediate or late PE. For calculations of sensitivity and specificity to determine the best cut-off values for early, intermediate and late PE, all the information was processed into ROC curves. The assessment of preeclampsia risk in the first trimester using an ultrasound plus the FMF On-Line Risk Calculator demonstrated a significant (p 0.05) area under the ROC curve for early, intermediate and late preeclampsia. The best risk cut-off values were defined as 2.1% for early, 2.5% for intermediate and 3.5% for late preeclampsia. The first trimester US plus the FMF On-Line Risk Calculator tool was useful and applicable when assessing the risk for preeclampsia in a specific pregnant Brazilian population.