Protein expression trends of DNMT1 in gastrointestinal diseases:From benign to precancerous lesions to cancer

作     者：Tian-Miao Ma Li-Ping Sun Nan-Nan Dong Ming-Jun Sun Yuan Yuan 

作者机构：Department of Gastroenterologythe First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Tumor Etiology and Screening Department of Cancer Institute and General Surgerythe First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2019年第11卷第12期

页      面：1141-1150页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Gastric cancer Colorectal cancer DNMT1 Precancerous lesion Intraepithelial neoplasia 

摘      要：BACKGROUND In recent years,the incidence of gastrointestinal(GI)cancer in China has increased *** detection and appropriate therapy are considered to be the key to treat GI ***1 takes an active part in the advancement of GI cancer,which will change as the disease *** its expression characteristics in the dynamic variations of GI carcinogenesis are still *** To investigate the expression characteristics of DNMT1 in different GI *** We detected the expression of DNMT1 in 650 cases of different GI diseases by immunohistochemistry,including 90 cases of chronic superficial gastritis(CSG),72 cases of atrophic gastritis with intestinal metaplasia(AG/GIM),54 cases of low-grade intraepithelial neoplasia(GLIN),66 cases of high-grade intraepithelial neoplasia(GHIN),71 cases of early gastric cancer(EGC),90 cases of normal intestinal mucosa(NIM),54 cases of intestinal low-grade intraepithelial neoplasia(ILIN),71 cases of intestinal high-grade intraepithelial neoplasia(IHIN),and 82 cases of early colorectal cancer(ECRC).RESULTS In the CSG group,all cases showed weakly positive or negative expression of ***,in other four groups(AG/GIM,GLIN,GHIN,and EGC),the positive expression rate gradually increased with the severity of the diseases;the negative or weakly positive cases accounted for 55.56%(40/72),38.89%(21/54),1.52%(1/66),and 1.41%(1/71),***,the moderately positive cases were 44.44%(32/72),57.41%(31/54),80.30%(53/66),and 43.66%(31/71),*** strongly positive cases only existed in the GLIN(3.70%,2/54),GHIN(18.18%,12/66),and EGC(54.93%,39/71)*** differences between any two groups were statistically significant(P0.05).Similarly,in the NIM group,cases with weakly positive expression of DNMT1 were predominant(91.11%,82/90),and the rest were moderately positive cases(8.89%,8/90).In the ILIN,IHIN,and ECRC groups,the rates of cases with weak or negative expression of DNMT1 were 46.30%(25/54