Systematic Investigation of Berberine for Treating Hepatocellular Carcinoma Based on Network Pharmacology

作     者：MU Jie LIU Hai-Xia TANG Fei-Fei LIU Shu-Ling FENG Tian-Yi WANG Xue-Qian WANG Qing-Guo CHENG Fa-Feng 穆杰;刘海霞;汤菲菲;刘姝伶;冯天意;王雪茜;王庆国;程发峰

作者机构：Key Laboratory of Syndrome and Formula Foundation ResearchMinistry of EducationBeijing University of Chinese MedicineBeijing 100029China b.Teaching and Research Department of Clinical Foundation of Chinese Medicine of Synopsis of Golden ChamberSchool of Basic Medical SciencesBeijing University of Chinese MedicineBeijing 100029China 

出 版 物：《Digital Chinese Medicine》 (数字中医药（英文）)

年 卷 期：2019年第2卷第3期

页      面：127-135页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：funding support from the General Program of National Natural Science Foundation of China (No. 81774122) College Level Project of Beijing University of Chinese Medicine (No. 2019-JYB-XS002) 

主　　题：Berberine Hepatocellular carcinoma(HCC) Network pharmacology Immunity Apoptosis Antitumor 

摘      要：Objective Liver cancer is the 4th leading cause of cancer death worldwide,and hepatocellular carcinoma(HCC)accounts for the largest proportion of these *** is a quaternary amine compound extracted from plants such as Coptidis Rhizoma(Huang Lian,黄连)and Phellodendri Chinensis Cortex(Huang Bo,黄柏)and is considered as a potential candidate for treating *** study used network pharmacology methods,reveal the core mechanism of action of berberine in the treatment of HCC,clarify its medicinal value,and locate the anti-tumor mechanism of *** Structural information of Berberine(PubChem CID:2353)was obtained from the NCBI PubChem;ADME parameter were obtained from the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database;Berberine prediction targets were collected from symmap,stitch and targetnet databases;HCC significant targets were retrieved from *** and Liverome;A PPI network was established at STRING,Prediction target of berberine therapy for HCC are collected by gene mapping;The core target,pathway,biological process(BP),cellular component(CC),and molecular function(MF)of berberine in the treatment of HCC were predicted by topological analysis and enrichment analysis;the visualizedtarget pathwaynetwork diagram of berberine in the treatment of HCC was established by the software of *** Through PubChem and tcmsp databases,the good drugforming properties of berberine were identified;32 prediction targets of berberine were collected in symmap,stitch and targetnet databases;566 related targets of HCC were collected in *** and liverome databases;10 targets of berberine treatment for HCC were predicted by gene mapping,and a PPI with 10 nodes and 34 edges was established Through topological analysis and enrichment analysis,6 topologically important targets,6 related pathways and 16 BP,6 cc and 7 MF involved in Berberine treatment of HCC were *** The anticancer effect of berberine is mainly in