Antiretroviral Therapeutic Profile in Patients Living with HIV with Chronic Kidney Disease

作     者：Yawovi Mawufemo Tsevi Lidaw Déassoua Bawe Komi Dzidzonu Nemi Abdou Razak Moukaila Akessiwe Akouda Patassi Majesté Ihou Majesté Ihou 

作者机构：Department of Nephrology and Hemodialysis University Hospital Sylvanus Olympio of Lomé University of Lome-Togo Departement of Infectious and Tropical Diseases University Hospital Sylvanus Olympio of Lomé University of Lome-Togo Department of Internal Medicine University Hospital Sylvanus Olympio Lomé University of Lome-Togo 

出 版 物：《Advances in Infectious Diseases》 (传染病进展（英文）)

年 卷 期：2019年第9卷第3期

页      面：252-262页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Therapeutic Profile CKD HIV HAART Togo 

摘      要：Chronic Kidney disease (CKD) is one of the important complications during HIV infection. The advent of Highly Active Antiretroviral Therapy (HAART) has significantly improved the prognosis of these patients. This was a descriptive and analytical cross-sectional study of people living with HIV received at the Ambulatory Treatment Center (ATC) of the Department of Infectious Diseases of Sylvanus Olympio University Hospital (CHU-SO). The study period was 6 months from January 1, 2018 to June 30, 2018. A total of 234 patients were enrolled during the study period. The mean age of patients at initiation of treatment was 42.07 ± 9.49 years with an average duration of follow-up under antiretroviral treatment of 5.61 ± 3.22 years. The female sex was predominant (70.09%) and a sex ratio (M/F) of 0.43. Most people living with HIV were mostly classified at clinical stage 2 (30.77) and 3 (31.62%) of WHO at initiation of HAART. The mean CD4 rate was 223.30 ± 143.764 at initiation of HAART and 462.58 ± 202.723 at the time of study. The frequency of CKD was 11.11%. The majority of patients were placed in a fixed combination of Tenofovir/Lamivudine/Efavirenz in a proportion of 81.20% of cases. In univariate analysis shows that age greater than 45 years (p = 0.017). Pathological proteinuria (p = 0.021) were associated with CKD. In multivariate analysis, only age (p = 0.045) and pathological proteinuria (p = 0.035) were significantly associated with CKD.