The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: III Pharmacological Studies

作     者：Peter K. Panegyres Emily R. Atkins 

作者机构：不详 

出 版 物：《Neuroscience & Medicine》 (神经系统科学与医药（英文）)

年 卷 期：2011年第2卷第3期

页      面：397-409页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Amyloid Precursor Protein APP Genes Dementia Alzheimer’s Disease 

摘      要：Pharmacological studies reveal APP and Aβ have interactions with glutamate and calcium, cytokines, copper/zinc chelators, secretases and presenilins, nicotinic receptors, acetycholinesterase, neurotrophins, non-steroidal anti-inflame-matory drugs, monoclonal antibodies to Aβ, protease inhibitors, oestrogen, homocysteine, immediate early genes such as c-fos or c-jun and cholesterol. These functional and pharmacological observations highlight the need for greater understanding of APP and Aβ in brain function and have implications for clinical trials.