Graphene-Coated Optical Fiber SPR Biosensor for BRCA1 and BRCA2 Breast Cancer Biomarker Detection:a Numerical Design-Based Analysis

作     者：Md.Biplob HOSSAIN Md.Muztahidul ISLAM Lway Faisal ABDULRAZAK Md.Masud RANA Tarik Bin Abdul AKIB Mehedi HASSAN Biplob HOSSAIN;Muztahidul ISLAM;Lway Faisal ABDULRAZAK;Masud RANA;Tarik Bin Abdul AKIB;Mehedi HASSAN

作者机构：Dept.of Electrical and Electronic EngineeringJashore University of Science and TechnologyJashore-7408Bangladesh Dept.of Electrical and Electronic EngineeringBangladesh Army University of Engineering and TechnologyNatore-6431Bangladesh Dept.of Computer ScienceCihan University SlemaniSulaimaniya-46001Iraq Dept.of Electrical and Electronic EngineeringRajshahi University of Engineering&TechnologyRajshahi-6402Bangladesh 

出 版 物：《Photonic Sensors》 (光子传感器（英文版）)

年 卷 期：2020年第10卷第1期

页      面：67-79页

核心收录：

学科分类：081702[工学-化学工艺] 080202[工学-机械电子工程] 08[工学] 0817[工学-化学工程与技术] 0802[工学-机械工程] 

主　　题：ATR BRCA1 BRCA2 cancer DNA hybridization graphene,SPR SRF 6174delT 916delTT 

摘      要：This paper provides a simple hybrid design and numerical analysis of the graphene-coated fiber-optic surface plasmon resonance(SPR)biosensor for breast cancer gene-1 early onset(BRCA1)and breast cancer gene-2 early onset(BRCA2)genetic breast cancer *** specific mutations named 916delTT and 6174delT in the BRCA1 and BRCA2 are selected for numerical detection of breast *** sensor is based on the technique of the attenuated total reflection(ATR)method to detect deoxyribonucleic acid(DNA)hybridization along with individual point mutations in BRCA1 and BRCA2 *** have numerically shown that momentous changes present in the SPR angle(minimum:135%more)and surface resonance frequency(SRF)(minimum:136%more)for probe DNA with various concentrations of target DNA corresponding to a mutation of the BRCA1 and BRCA2 *** variation of the SPR angle and SRF for mismatched DNA strands is quite negligible,whereas that for complementary DNA strands is considerable,which is essential for proper detection of genetic biomarkers(916delTT and 6174delT)for early breast *** last,the effect of electric field distribution in inserting graphene layer is analyzed incorporating the finite difference time domain(FDTD)technique by using Lumerical FDTD solution commercial *** the best of our knowledge,this is the first demonstration of such a highly efficient biosensor for detecting BRCA1 and BRCA2 breast ***,the proposed biosensor opens a new window toward the detection of breast cancers.