Characterization of the amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid

作     者：Jia Kong 

作者机构：School of Life Science Tianjin University Tianjin 300072 China Collaborative Innovation Center of Chemical Science and Engi- neering Tianjin 300072 China Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health Baltimore MD 21205 USA Institute of Virology and AIDS Research First Hospital of JilinUniversity Changchun 130061 China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2014年第5卷第12期

页      面：954-957页

核心收录：

学科分类：071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 090102[农学-作物遗传育种] 0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 0817[工学-化学工程与技术] 0703[理学-化学] 0901[农学-作物学] 0836[工学-生物工程] 

基　　金：supported in part by funding from the Chinese Ministry of Science and Technology Tianjin Research Program of Application Foundation and Advanced Technology 

主　　题：Deletion Construct Stalk Domain Tripartite Motif Protein Capsid Binding HEK293T Cell Lysate 

摘      要：Dear Editor More than 50 years have passed since the myxovirus resis- tance （MX） genes were first discovered and found to suppress infection with influenza viruses in mice （Lindenmann, 1962）. Like most mammals, mice carry two MXgenes, MX1 and MX2, which have arisen by gene duplication; both of these genes exhibit antiviral activity against a wide range of viruses （Liu et al., 2013）. Humans also have two MX genes, encoding the MxA and MxB proteins, which are interferon-induced, dynamin- like large molecular weight guanosine triphosphatases （GTP- ases）. The antiviral functions of MxA have been deeply explored： MxA can protect cells from infection by multiple groups of pathogenic DNA and RNA viruses, such as influenza A virus and hepatitis B virus （Liu et al., 2013）.