Symptoms of Early Cancer Especially Barrett’s Carcinoma
Symptoms of Early Cancer Especially Barrett’s Carcinoma作者机构：Department of Visceral- and Vascular Surgery University of CologneDepartment of Visceral- and Vascular Surgery University of CologneDepartment of Visceral- and Vascular Surgery University of Cologne Cologne GermanyCologne GermanyCologne Germany
出 版 物：《The Chinese-German Journal of Clinical Oncology》 (中德临床肿瘤学杂志（英文版）)
年 卷 期：2004年第3卷第4期
页 面：210-212页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：heartburn GERD Barrett’s-esophagus adenocarcinoma of the esophagus symptoms
摘 要：The incidence of the adenocarcinoma of the esophagus (AC) has been rising exponentially in the Western World within the last 30 years. The reasons for this increase are not yet understood. Massive and long lasting gastroesophageal re?ux causes the Barrett’s esophagus which is considered to be a precancerosis. Therefore early diagnosis and appropriate treatment of gastroesophageal re?ux is essential for the prevention of this tumor. This makes heartburn the leading clinical symptom in the patient’s history. In patients with heartburn it is possible to early endoscopically diagnose a Barrett’s esophagus or adenocarcinoma of the esophagus. However only few patients with this increased risk receive an index-endoscopy. In clinical studies a high rate of early carcinomas could be found and could be treated with mucosectomie or ablation. The majority of patients with AC present with symptoms suggestive of progressed disease such as dysphagia or weight loss. The prognosis in patients in late disease stages are with a 5-year survival of only 30% far worse than in patients with early carcinoma (85%). However the early symptoms such as heartburn or regurgitation are unspeci?c and make an e?ective diagnostical strategy di?cult. To optimize screening it would be bene?cial to identify patients with high risk for the development of adenocarcinoma of the esophagus.
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