Functional delivery vehicle of organic nanoparticles in inorganic crystals

作     者：Linlin Kong Xinyi Jin Dapeng Hu Leyun Feng Dong Chen Hanying Li 

作者机构：Institute of Process EquipmentCollege of Energy EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Fluid Power and Mechatronic SystemsZhejiang UniversityHangzhou 310027China MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationState Key Laboratory of Silicon MaterialsDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2019年第30卷第12期

页      面：2351-2354页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China (Nos.21878258,11704331 and 51625304) “the Fundamental Research Funds for the Central Universities” (No. 2018QNA4046) 

主　　题：Nanoparticle Calcite crystal Encapsulation Chlorophyll Dual-pH responses 

摘      要：Encapsulation of bioactive substances for extended shelf life and controlled,targeted release is critical for their applications in food and drug ***,a new method has been developed to encapsulate bioactive molecules in the crystal composites,showing greatly enhanced stability and unique pHtriggered ***,a model bioactive,is first loaded in shellac nanoparticles via coprecipitation with a high encapsulation efficiency,and then the chlorophyll-loaded nanoparticles are incorporated into calcite crystals grown from a gel media containing the *** the protection of shellac nanoparticles and calcite crystals,chlorophyll shows excellent stability even under *** chlorophyll could only be released by first dissolving the calcite crystals under acidic condition and then dissolving the shellac nanoparticles under alkaline *** unique pHtriggered release mimics the pH change from acidic in the stomach to alkaline in the intestine and is thus well suited for controlled,targeted intestinal *** work suggests that the crystal composites are an ideal delivery vehicle for the functional design of bioactive molecules.