Synthesis of serotonin transporter imaging agent [^(125)I]ADAM

作     者：LUChun-Xiong WUChun-Ying JIANGQuan-Fu CHENZheng-Ping ZHANGTong-Xing LIXiao-Ming WANGSong-Pei 

作者机构：JiangsuInstituteofNuclearMedicineWuxi214063 

出 版 物：《Nuclear Science and Techniques》 (核技术（英文）)

年 卷 期：2005年第16卷第3期

页      面：153-155页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100106[医学-放射医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by a grant (RC2002068) from "135" Medicinal Momentous Project of Jiangsu Province and by a grant from Department of Personnel Jiangsu Province 

主　　题：复合胺传输 成象介质 TLC 合成工艺 放射医学 

摘      要：The synthesis of serotonin transporter imaging agent [125I] -2-((2-((dimethylamino)methyl)phenyl) thio)-5-iodophenylamine([125I] ADAM) was reported. The chemical structure of the labeling precursor 5- (tributyl- stannyl) -2-((2-((dimethylamino)methyl)phenyl)thio)phenylamine and all its intermediates were verified by IR,1HNMR and MS. The radioiodinated compound was prepared using iododestannylation reaction by hydrogen peroxide. Final radiochemical purity was above 95% determined by TLC.