Proteins:From sequence to structure

作     者：郑伟谋 

作者机构：Institute of Theoretical Physics Chinese Academy of Sciences 

出 版 物：《Chinese Physics B》 (中国物理B（英文版）)

年 卷 期：2014年第23卷第7期

页      面：107-113页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070104[理学-应用数学] 0701[理学-数学] 

基　　金：supported by the National Natural Science Foundation of China (Grant Nos. 11175224 and 11121403) 

主　　题：proteins protein sequence protein structures protein folding 

摘      要：Protein sequences as special heterogeneous sequences are rare in the amino acid sequence space. The specific sequen- tial order of amino acids of a protein is essential to its 3D structure. On the whole, the correlation between sequence and structure of a protein is not so strong. How well would a protein sequence contain its structural information？ How does a sequence determine its native structure？ Keeping the globular proteins in mind, we discuss several problems from sequence to structure.