Local neuronal circuits that may shape the discharge patterns of inferior collicular neurons

作     者：Zi-Ying Fu Hui-Xian Mei Liang Cheng Jing Bai Jia Tang Philip Hung-Sun Jen Qi-Cai Chen 

作者机构：School of Life Sciences & Hubei Key Laboratory of Genetic Regulation and Integrative Biology Central China Normal University Division of Biological Sciences University of Missouri-Columbia 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2013年第29卷第5期

页      面：541-552页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：supported by grants from the National Natural Science Foundation of China (31070971 31000959) 

主　　题：inferior collicular neuron discharge pattern synaptic mechanism local neuronal circuit in vivo intracellular recording 

摘      要：The discharge patterns of neurons in auditory centers encode information about ***,few studies have focused on the synaptic mechanisms underlying the shaping of discharge patterns using intracellular recording ***,we investigated the discharge patterns of inferior collicular（IC）neurons using intracellular recordings to further elucidate the mechanisms underlying the shaping of discharge *** in vivo intracellular recording conditions,recordings were obtained from 66 IC neurons in 18 healthy adult mice（Mus musculus,Km）under free *** of these neurons fired bursts of action potentials（APs）to auditory stimuli and the remaining eight just generated local responses such as excitatory（n=4）or inhibitory（n=4）postsynaptic *** on the APs and subthreshold responses,the discharge patterns were classified into seven types：phasic（24/58,41.4%）,phasic burst（8/58,13.8%）,pauser（4/58,6.9%）,phasic-pauser（1/58,1.7%）,chopper（2/58,3.4%）,primary-like tonic（14/58,24.1%）and sound-induced inhibitory（5/58,8.6%）.We concluded that（1）IC neurons exhibit at least seven distinct discharge patterns;（2）inhibition participates in shaping the discharge pattern of most IC neurons and plays a role in sculpting the pattern,except for the primary-like tonic pattern which was not shapedby inhibition;and（3）local neural circuits are the likely structural basis that shapes the discharge patterns of IC neurons and can be formed either in the IC or in lower-level auditory structures.