A Novel Prognostic Approach to Predict Recovery in Patients with Chronic Disorders of Consciousness

作     者：Wangxiao Bao Xiaoxia Li Benyan Luo 

作者机构：Department of Neurology First Affiliated Hospital Collaborative Innovation Center for Brain Science Zhejiang University School of Medicine 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2019年第35卷第5期

页      面：953-954页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by grants from National Natural Science Foundation of China (81870817, and 81671143) the Science and Technology Plan of Zhejiang Province, China (2017C03011) 

主　　题：Chronic Disorders of Consciousness Prognostic 

摘      要：Severe brain injury can lead to acute or chronic disorders of consciousness (DOC), and the latter represents a more critical challenge in diagnosis and management. For most chronic unconsciousness survivors with preserved sleepwake cycles, including vegetative state (VS) and minimally conscious state (MCS), levels of consciousness are commonly monitored and determined based on behavioral evidence. VS, also termed unresponsive wakefulness syndrome (UWS), is characterized by complete absence of awareness and may be associated with poor recovery, while MCS exhibit discernible behavioral signs of environmental or self- awareness [1]. Since nearly 40% patients in MCS are initially misdiagnosed as VS/UWS due to the limitation of the existing diagnostic criterion, it is therefore necessary to define the accurate diagnostic and prognostic categorization for long-term outcome [2].