The effect of Chinese herbal medicine“heche assisted pregnancy recipe”on endometrial estrogen and progesterone receptor,proliferating cell nuclear antigen and vascular endothelial growth factor in the patients with infertility

作     者：刘效群 阚国英 彭玉梅 樊瑞琴 齐惠敏 焦妹芬 李忠 石彬 尹桂然 董锡月 Liu Xiao-qun Kan Guo-ying Peng Yu-mei Fan Rui-qin Qi Hui-min Jiao Mei-fen Li Zhong Shi Bin Yin Gui-ran Dong Xi-yue 1.Hebei Research Institute for Family Planning,Shijiazhuang 050071,China2.Department of Gynecology & Obstetrics,Zhengding Hospital,Zhengding 050800,China3.Department of Gynecology & Obstetrics,the Second Hospital,Hebei Medical University,Shijiazhuang 050071,China

作者机构：Hebei Research Institute for Family PlanningShiji-azhuang 050071China Department of Gynecology & ObstetricsZhengding HospitalZhengding 050800China Department of Gynecology & Obstetricsthe Second HospitalHebei Medical UniversityShijiazhuang 050071China 

出 版 物：《生殖医学杂志》 (Journal of Reproductive Medicine)

年 卷 期：2003年第12卷第Z1期

页      面：33-39页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100211[医学-妇产科学] 10[医学] 

主　　题：Heche assisted pregnancy recipe Infertility Endometrium Receptor, estrogen Receptor, progesterone Proliferating cell nuclear antigen Vascular endothelial growth factor 

摘      要：Objectives:To investigate the effect of Chinese herbal medicineheche assisted preg-nancy recipe (HCAPR) on estrogen receptor(ER), progesterone receptor (PR), pro-lifierating cell nuclear antigen(PCNA) and vascular endothelial growth factor (VEGF)in endometrium of infertile ***: The S-P immunohistochemical assay was used to observe expression ofER, PR , PCNA and VEGF in late proliferative phase before and after the HCAPR ***: After the treatment, the expression of ER,PR,PCNA and VEGF in nucleiof glandular epithelium and stromal cells was significantly stronger (all P0. 001) re-spectively than that before treatment , especially the expression of PCNA and ***: These results suggest that traditional Chinese medicine HCAPR oftonifying kidney and regulating menstruation increased the synthesis of ER,PR, PCNAand VEGF, which may promote normal growth and development of the endometrium ,improve the micro-environment of the endometrium, and enhance uterine *** evidence may provide theoretical basis for therapy infertility with Chinese herbalmedicine.