Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history
Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history作者机构:Department of Medical Sciences and Public HealthUniversity of CagliariMonserrato 09042Italy Department of Systems MedicineUniversity of Rome"Tor Vergata"Rome 00133Italy
出 版 物:《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文版))
年 卷 期:2019年第25卷第37期
页 面:5676-5686页
核心收录:
主 题:Nonalcoholic fatty liver disease Liver fibrosis Inflammatory bowel disease Risk factors Dietary habits
摘 要:BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a frequently reported condition in patients with inflammatory bowel disease(IBD).Both intestinal inflammation and metabolic factors are believed to contribute to the pathogenesis of IBDassociated *** To evaluate the prevalence of steatosis and liver fibrosis(LF)in a cohort of IBD patients and the identification of metabolic-and IBD-related risk factors for NAFLD and *** IBD patients were consecutively enrolled from December 2016 to January ***,anthropometric and biochemical data were collected so as eating *** ultrasound and transient elastography were performed to evaluate the presence of NAFLD and LF *** A total of 178 consecutive patients were enrolled and included in the analysis(95 Ulcerative colitis,83 Crohn’s disease).NAFLD was detected by imaging in 72(40.4%)*** between patients with and without NAFLD showed no significant differences in terms of IBD severity,disease duration,location/extension,use of IBD-related medications(i.e.,steroids,anti-TNFs,and immunomodulators)and *** was significantly associated with the presence of metabolic syndrome[MetS;odds ratio(OR):4.13,P=0.001]and obesity defined by body mass index(OR:9.21,P=0.0002).IBD patients with NAFLD showed higher caloric intake and lipid consumption than those without NAFLD,regardless disease *** the multivariate analysis,male sex,advanced age and high lipid consumption were independent risk factors for the development of *** increased liver stiffness was detected in 21 patients(16%)and the presence of MetS was the only relevant factor associated to LF(OR:3.40,P=0.01).CONCLUSION In this study,we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population.