Manifestations and outcomes of leptospirosis during local outbreaks in high endemic districts of Sri Lanka: A retrospective multi-center study

作     者：Thilini Nisansala Kanchana Bandara Manjula Weerasekera Chinthika Gunasekara Chamil Marasinghe Chandika D.Gamage Neluka Fernando Nilantha Ranasinghe 

作者机构：Department of MicrobiologyFaculty of Medical SciencesUniversity of Sri JayewardenepuraSri Lanka Department of Basic SciencesFaculty of Allied Health SciencesGeneral Sir John Kotelawala Defence UniversitySri Lanka Department of MedicineFaculty of Medical SciencesUniversity of Sri JayewardenepuraSri Lanka Department of MicrobiologyFaculty of MedicineUniversity of PeradeniyaSri Lanka Base HospitalPanaduraSri Lanka 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2019年第12卷第10期

页      面：442-449页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：funded by grants awarded by University of Sri Jayewardenepura Sri Lanka(No.ASP/01/RE/MED/2015/37 ASP/01/RE/MED/2016/48 and ASP/01/RE/MED/2017/29) 

主　　题：Case definitions Diagnosis Leptospirosis Sri Lanka 

摘      要：Objective:To determine the clinical presentations and disease outcomes of suspected and confirmed cases of leptospirosis from 3 high endemic districts of Sri Lanka,during outbreaks reported between 2013 and ***:The retrospective multi-center study was carried out during 2013-2017 in 5 selected hospitals representing 3 high endemic districts in Sri *** suspected leptospirosis patients were recruited according to the Communicable Disease Epidemiology Profile Sri Lanka,*** was confirmed by either single microscopic agglutination test titre 1:400 or by positive polymerase chain reaction(PCR)test ***:Out of 372 clinically suspected cases,29.00%were confirmed as leptospirosis cases by either microscopic agglutination test(50.00%)or positive polymerase chain reaction(52.77%)and 12.90%were presumptively identified as *** symptoms(headache,vomiting,jaundice and dyspnoea)and variations in haematological parameters(haemoglobin,platelet count)and biochemical parameters(serum creatinine,serum urea,serum bilirubin and C-reactive protein)were associated with confirmed leptospirosis(P0.05).Acute kidney injury,meningitis,myocarditis,pulmonary haemorrhage and acute liver failure was seen among 21.30%,12.04%,6.48%,6.48%,5.56%,respectively with 4.63%fatality among the leptospirosis confirmed *** sensitivity,specificity,positive predictive value and negative predictive value of the case definition of Ministry of Health,Sri Lanka were 96.29%,9.09%,31.13%and 85.71%,respectively,when benchmarked against either positive polymerase chain reaction or microscopic agglutination test as the gold ***:Acute kidney injury is the predominant complication observed among the leptospirosis confirmed ***,pulmonary haemorrhage is predominantly associated with *** case definition of Ministry of Health,Sri Lanka is found to have higher sensitivity and enabled the screening of all probable cas