Functional Polymers for Chromatographic Enantiomer Separation

作     者：S.Allenmark L.Thunberg 

作者机构：Department of ChemistryGteborg UniversitySE-41296 GteborgSwedenMedicinal ChemistryAstraZeneca R&D MlndalSE-43183 MlndalSweden 

出 版 物：《复旦学报（自然科学版）》 (Journal of Fudan University：Natural Science)

年 卷 期：2005年第44卷第5期

页      面：653-654页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

主　　题：聚合体 色析法 对映体分离 固定相 有机物 合成方法 

摘      要：Today, methods to obtain pure enantiomers of organic compounds are of extreme importance, not the least due to the demands imposed on the pharmaceutical industry. Separation of the two enantiomers in a racemate is necessary in order to study possible differences in biological activity. Consequently, research on methods for direct chromatographic resolution by means of columns containing a chiral stationary phase (CSP) has been intense during the last decades and a wide variety of CSPs,many of which commercially available,exist *** CSPs have been made from naturally occurring polymers (cellulose, amylose) via suitable derivatization, as well as either by polymerization of chiral monomers or via asymmetric catalysis to yield linear, isotactic polymers of a predominantly single-handed helicity. An excellent review of the field[1], with special emphasis on preparative applications, was published in 1994.