Overexpression of Annexin A2 Is Associated with Abnormal Ubiquitination in Breast Cancer

作     者：Shishan Deng Baoqian Jing Tianyong Xing Lingmi Hou Zhengwei Yang 

作者机构：Department of AnatomyNorth Sichuan Medical CollegeNanchong 637007China Institute of Immunology and Molecular BiologyNorth Sichuan Medical CollegeNanehong 637007China Department of General SurgeryThe Affiliated Hospital of North Sichuan Medical CollegeNanchong 637007China Morphometric Research LaboratoryNorth Sichuan Medical CollegeNanchong 637007China 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2012年第10卷第3期

页      面：153-157页

核心收录：

学科分类：071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0817[工学-化学工程与技术] 0714[理学-统计学（可授理学、经济学学位）] 0703[理学-化学] 100214[医学-肿瘤学] 0701[理学-数学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 10[医学] 

基　　金：supported by grants from the Sichuan Science and Technology Support Program (Grant No.2009SZ0116) Natural Science Foundation of China(Grant No. 81172496) Sichuan Department of Education (Grant No. 10ZA075) 

主　　题：Annexin A2 Breast cancer Immunoproteomics Ubiquitination 

摘      要：Abnormal expression of annexin A2 contributes to metastasis and infiltration of cancer cells. To elucidate the cause of abnormal expres- sion of annexin A2, Western blotting, immunoproteomics and immunohistochemical staining were performed to analyze differentially ubiquitinated proteins between fresh breast cancer tissue and its adjacent normal breast tissue from five female volunteers. We detected an ubiquitinated protein that was up-regulated in the cancer tissue, which was further identified as annexin A2 by mass spectrometry. These results suggest that abnormal ubiquitination and/or degradation of annexin A2 may lead to presence of annexin A2 at high level, which may further promote metastasis and infiltration of the breast cancer cells.