Natural products as a crucial source of anti-inflammatory drugs: recent trends and advancements
作者机构：State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing China
出 版 物：《Traditional Medicine Research》 (TMR传统医学研究)
年 卷 期：2019年第4卷第5期
页 面：257-268页
基 金：This work was supported by grants from the National Key Technology R & D Program “New Drug Innovation” of China (No. 2017ZX09101003-008-003) the Natural Science Foundation of China (No. 81773932).
主 题：Natural products Anti-inflammation Traditional Chinese medicine Mechanism of action Drug target
摘 要：Natural active molecules are key sources of modern innovative drugs. Particularly, a great amount of natural active molecules have been reported to possess promising therapeutic effects on inflammatory diseases, including asthma, rheumatoid arthritis, hepatitis, enteritis, metabolic disorders and neurodegenerative diseases. However, these natural active molecules with various molecular structures usually exert anti-inflammatory effects through diversiform pharmacological mechanisms, which is necessary to be summarized systematically. In this review, we introduced the current major anti-inflammatory natural active molecules based on their chemical structures, and discussed their pharmacological mechanisms including anti-inflammatory molecular signaling pathways and potential target proteins, which providing a referential significance on the development of novel anti-inflammatory drugs, and also revealing new therapeutic strategies for inflammatory diseases.
维普期刊数据库