Prevalence of Rifampicin Resistance and Associated Risk Factors among Suspected Multidrug Resistant Tuberculosis Cases in TB Centers Mogadishu-Somalia: Descriptive Study

作     者：Ahmed Y. Guled Ayub Hassan Elmi Bashir Mohamud Abdi Abdihamid Mohamed Ali Rage Fartun Mohamed Ali Abdullahi Hassan Abdinur Abdullahi Abdulle Ali Anab Adam Ahmed Khadra Abdullahi Ibrahim Salah Osman Mohamed Fos Ali Mire Omar Abdi Adem Ali Dirie Osman Ahmed Y. Guled;Ayub Hassan Elmi;Bashir Mohamud Abdi;Abdihamid Mohamed Ali Rage;Fartun Mohamed Ali;Abdullahi Hassan Abdinur;Abdullahi Abdulle Ali;Anab Adam Ahmed;Khadra Abdullahi Ibrahim;Salah Osman Mohamed;Fos Ali Mire;Omar Abdi Adem;Ali Dirie Osman

作者机构：Guuleed Hospital Mogadishu Somalia Faculty of Medicine Benadir University Mogadishu Somalia Department of Internal Medicine Benadir University Mogadishu Somalia 

出 版 物：《Open Journal of Respiratory Diseases》 (呼吸病期刊（英文）)

年 卷 期：2016年第6卷第2期

页      面：15-24页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Prevalence Risk Factors Tuberculosis Mogadishu 

摘      要：Introduction and Background: Multidrug-resistant tuberculosis (MDR-TB) has emerged as a significant global health concern. Patients who had failed previous TB treatment, relapsed after treatment, contacted known MDRTB patients or defaulted during previous treatment, and HIV patients are considered to be suspected and at high risk for developing drug resistant TB specially MDR-TB. However, there is little data available on the prevalence and trends of MDR tuberculosis in national level but luck of it in Mogadishu is our main concern. Methodology: This was a crosssectional, descriptive study involving all suspected MDR TB patients attended at the Mogadishu three Tb centers. Results: A total of 138 cases of suspected MDRTB patients were included in the study. Of these, 70 patients (51%) had rifampicin resistant-TB. Of the 138 study participants, 94 (68.62%) were between 21 - 40 years old that indicates the dominance of productive age group (21 - 40 years). Previous Tuberculosis treatment has been noted to be a major risk factor for development of multidrug resistance tuberculosis. MDR-TB prevalence is significantly higher in male than female patients. Conclusion and Interpretation: The prevalence of Rifampicin resistance among these high risk groups was significant. The high association of previous TB treatment to MDR-TB might be explained due to inappropriate anti-tubercular regimens, sub-optimal drugs, inadequate or irregular drug supply, unsatisfactory patient or clinician compliance, lack of supervision of treatment and absence of infection control measures in healthcare facilities. As the prevalence of MDRTB is high and yet the cases remain un-isolated in the community we recommend the MOH/NTP and funding agencies to facilitate establishment of MDRTB management centers earlier in Mogadishu in order to treat the MDRTB case otherwise it might Amplify of the incidence of this Emerging Disease.