Effect of dopamine neurotransmitter expression on sleep disorders in neurological inpatients
作者机构：Neurology DepartmentChangsha Third HospitalChina
出 版 物：《Journal of Hainan Medical University》 (海南医学院学报（英文版）)
年 卷 期：2019年第25卷第11期
页 面：28-32页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Research Foundation of Hunan Health and Family Planning Commission (132015-150)
主 题：Brain Dopamine Sleep disorder Nervous system
摘 要：Objective:To explore the effect of dopamine neurotransmitter expression on sleep disorders in neurological ***: Thirty-four patients with sleep disorders and 30 volunteers from February 2018 to November 2018 in the neurology department of our hospital were selected as the study subjects. They were divided into the observation group and the control group. 64 participants stopped taking stimulating drinks such as coffee and alcohol two weeks before the experiment. The sleep quality and depression were measured by the Pittsburgh Sleep Quality Index (PSQI) and Hamilton Depression Scale (HAMD). Degree of depression was examined by brain MRI. Two days later,11C-Raclopril labeled brain dopamine neurotransmitter binding to receptors was scanned by PET/CT. SPSS was used to analyze the correlation between dopamine neurotransmitters and sleep ***: The HAMD and PSQI scores of the observation group were significantly higher than those of the control group (P0.05).Conclusion: The decrease of dopamine receptor binding in patients with sleep disorders is related to the course of sleep disorders, suggesting that the decrease of dopamine expression and sleep disorders have clinical significance.
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