Effectiveness of electrochemical therapy in the treatment of lung cancers of middle and late stage

作     者：辛育龄 薛复舟 赵凤瑞 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：1997年第5期

页      面：59-63页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：辛育龄 Effectiveness 赵凤瑞 

摘      要：Objective To investigate the effect of electrochemical therapy (ECT) in the treatment of middle and late stage lung cancers. Methods Three hundred and eighty six cases (287 males and 99 females aged 25-78, with an average age of 51 years) with middle and late stage lung cancers were treated with ECT. Two hundred and three patients had squamous cell carcinoma, 138 adenocarcinoma and 45 undifferentiated cancer. Diameters of the cancers were respectively 4.0-6.0 cm in 153 cases, 6.1- 8.0 cm in 82 cases, 8.1-10.0 cm in 102 cases and over 10.0 cm in 49 cases. In this group, none was at stageⅠ, 103 cases were at stageⅡ, 89 cases at Ⅲa, 122 cases at Ⅲb and 72 cases at Ⅳ. Of the 386 cases, 152 cases (39.4%) also suffered from hypertension, heart disease etc. Anode and cathode platinum electrodes were inserted accurately into the tumour mass. Distance between two electrodes was 2.0-2.5 cm. Electrodes were connected to a special ECT instrument. The current was maintained at 6-8 V and 80-100 mA. One hundred coulombs are used for treating 1 cm diameter of tumour mass. Results Of the 386 cases, 99 cases (25.6%) achieved complete remission (CR), 179 cases (46.4%) achieved partial remission (PR), 59 cases (15.3%) had no change (NC) and 49 cases (12.7%) had progression of disease (PD). Effective rate (CR +PR) was 72% (278 cases). One to five year survival rates were 86.3%, 76.4%, 58.8%, 39.9% and 29.5%, respectively. Conclusions ECT is easy to use. It is effective, safe, less traumatic and makes patients recover quickly. This is a new and effective method to treat patients with tumours who are inoperable and can not receive chemotherapy or radiotherapy.