Genetic evidence for asymmetric blocking of higher-order chromatin structure by CTCF/cohesin

作     者：Yujia Lu Jia Shou Zhilian Jia Yonghu Wu Jinhuan Li Ya Guo Qiang Wu 

作者机构：MOE Key Lab of Systems BiomedicineCenter for Comparative BiomedicineState Key Lab of Oncogenes and Related GenesShanghai Cancer InstituteJoint International Research Laboratory of Metabolic&Developmental SciencesInstitute of Systems BiomedicineXin Hua HospitalShanghai Jiao Tong UniversityShanghai 200240China Present address:Ming Wai Lau Centre for Reparative MedicineKarolinska InstitutetHong KongChina MRC London Institute of Medical SciencesImperial College LondonLondon W120NNUK 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2019年第10卷第12期

页      面：914-920页

核心收录：

学科分类：07[理学] 0701[理学-数学] 070101[理学-基础数学] 

基　　金：This work was supported by Grants from MOST(2017YFA0504203,2018YFC1004504) the National Natural Science Foundation of China(31630039,91640118,and 31470820)to Q.W.Q.W.is a Shanghai Subject Chief Scientist 

主　　题：asymmetric precise chains 

摘      要：Dear Editor,Similar to higher-order folding of polypeptide chains into functional proteins,linear DNA molecules are spatially folded in a hierarchical and dynamic manner into three-dimensional(3D)functional chromatin structures in eukaryotic nuclei(Huang and Wu,2016;Rowley and Corces,2018).This dynamic folding is closely related to many nuclear processes such as DNA replication and repair,chromosomal translo­cation,recombination,and segregation,as well as RNA transcription,splicing,and *** particular,dynamic long-distance chromatin looping interactions,which result in close spatial contacts between distal enhancers and target promoters,are thought to play a role in controlling precise spatiotemporal as well as cell-type specific gene expression during animal development(Rowley and Corces,2018).Mammalian genomes contain numerous noncoding regula­tory elements that regulate these dynamic long-distance chromatin looping interactions.