Inhibition of the emergence of multi drug resistant Staphylococcus aureus by Withania somnifera root extracts

作     者：Shuvo Datta Nishith Kumar Pal Ashoke Kumar Nandy 

作者机构：Department of MicrobiologySchool of Tropical MedicineKolkata-700 073India Department of MicrobiologyIPGMER244 AJC Rose Road(UCM Building)Kolkata-700 020India Department of Clinical & Experimental PharmacologySchool of Tropical MedicineKolkata-700073India 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2011年第4卷第11期

页      面：917-920页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Withania somnifera Antibacterial activity MDR Staphylococcus aureus 

摘      要：Objective:To search systematically for an alternative therapy with compounds particularly from plant ***:Efficacy test of different root extracts of Withania somnifera(W. somnifera)(L) Dunal against multi drug resistant(MDR) Staphylococcus aureus(***) variants was performed following the agar well diffusion *** of susceptibility pattern of the isolates was carried out by employing disk diffusion method using standard antibiotic disks. Results:In vitro study with *** root extracts was found to be effective against all the MDR *** strains isolated from local and patient *** root extracts of WS showed different degree of effectiveness against the ***:The major active principles responsible for the antibacterial efficacy were mainly present in methanol(MeOH) extract and ethanol(EtOH) extracts as well as in butanol(BuOH) extract *** all the extracts the BuOH fraction was found to be most active against all the isolates but aqueous extract was the least active *** it may be concluded that the antimicrobials from *** may raise an alternative therapy for MDR staphylococcal infections in near future.