Microsponge based drug delivery system for augmented gastroparesis therapy:Formulation development and evaluation

作     者：Riyaz Ali M.Osmani Nagesh H.Aloorkar Bharati U.Thaware Parthasarathi K.Kulkarni Afrasim Moin Umme Hani Atul Srivastava Rohit R.Bhosale 

作者机构：Department of PharmaceuticsJSS College of PharmacyJSS UniversityMysuru 570015KarnatakaIndia Department of PharmaceuticsSatara College of PharmacySatara 415004MaharashtraIndia Department of PharmaceuticsCollege of PharmacyHail UniversityHail 81442Saudi Arabia 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2015年第10卷第5期

页      面：442-451页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

主　　题：Domperidone Drug delivery Gastroparesis Microsponges Sustained release 

摘      要：The intention behind the present work was to develop a microsponge based novel dosage form for sustained delivery of ***-emulsion solvent diffusion method was employed using Eudragit RS-100 with various drug-polymer ratios for the preparation of *** optimization purposes,several factors which affect microparticles’physical properties were *** techniques followed for the formed microsponges were DSC,FTIR,SEM,XRD and particle size analysis,along with morphology,drug loading and in vitro drug *** was found that there were no chemical interactions between drugs and polymers used as per DSC and FTIR *** drug-polymer ratio showed remarkable impact on drug content,encapsulation efficiency and particle *** micrographs revealed that microsponges were spherical in shape with porous surface,and had 104±0.22μm mean particle *** microsponges were then loaded in capsules followed by in vitro drug release study;which depicted that microsponges with drug-polymer ratio of 1:2 were more proficient to give extended drug release of 76.38%at the end of 8 h,superior in contrast to conventional marketed formulation Domstal®,which got exhausted incredibly earlier by releasing 82.57%drug at the end of 1⁄2 h ***,the developed microsponge based formulation of domperidone would be an expectant,promising substitute to conventional therapy of gastroparesis,emesis and alike gastric ailments.