Microsponge based drug delivery system for augmented gastroparesis therapy:Formulation development and evaluation
微海绵基础的药物输送系统增强胃疗法：制定开发和评估作者机构：Department of PharmaceuticsJSS College of PharmacyJSS UniversityMysuru 570015KarnatakaIndia Department of PharmaceuticsSatara College of PharmacySatara 415004MaharashtraIndia Department of PharmaceuticsCollege of PharmacyHail UniversityHail 81442Saudi Arabia
出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)
年 卷 期：2015年第10卷第5期
页 面：442-451页
核心收录：
学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学]
主 题：Domperidone Drug delivery Gastroparesis Microsponges Sustained release
摘 要：The intention behind the present work was to develop a microsponge based novel dosage form for sustained delivery of ***-emulsion solvent diffusion method was employed using Eudragit RS-100 with various drug-polymer ratios for the preparation of *** optimization purposes,several factors which affect microparticles’physical properties were *** techniques followed for the formed microsponges were DSC,FTIR,SEM,XRD and particle size analysis,along with morphology,drug loading and in vitro drug *** was found that there were no chemical interactions between drugs and polymers used as per DSC and FTIR *** drug-polymer ratio showed remarkable impact on drug content,encapsulation efficiency and particle *** micrographs revealed that microsponges were spherical in shape with porous surface,and had 104±0.22μm mean particle *** microsponges were then loaded in capsules followed by in vitro drug release study;which depicted that microsponges with drug-polymer ratio of 1:2 were more proficient to give extended drug release of 76.38%at the end of 8 h,superior in contrast to conventional marketed formulation Domstal®,which got exhausted incredibly earlier by releasing 82.57%drug at the end of 1⁄2 h ***,the developed microsponge based formulation of domperidone would be an expectant,promising substitute to conventional therapy of gastroparesis,emesis and alike gastric ailments.
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