Risk of cancer,with special reference to extra-intestinal malignancies,in patients with inflammatory bowel disease
Risk of cancer,with special reference to extra-intestinal malignancies,in patients with inflammatory bowel disease作者机构：Department of Gastroenterology Hospital Universitario de Fuenlabrada 28942 Madrid Spain Department of Pathology Hospital Universitario de Fuenlabrada28942 Madrid Spain
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2013年第19卷第48期
页 面：9359-9365页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Extra-intestinal cancer Inflammatory bowel disease Cancer risk Background population Urothelial carcinoma Appendiceal mucinous cystadenoma Neuroendocrine carcinoma Rectal carcinoid
摘 要：AIM:To determine the incidence and characteristics of intestinal and extra-intestinal cancers among patients with inflammatory bowel disease in a Spanish hospital and to compare them with those of the local ***:This was a prospective,observational,7-year follow-up,cohort *** incidence,incidence rates based on person-years of follow-up and relative risk were calculated for patients with inflammatory bowel disease and compared with the background *** incidence of cancer was determined using a hospital-based data registry from Hospital Universitario de *** data and details about time from diagnosis of inflammatory bowel disease to occurrence of cancer,disease extent,inflammatory bowel disease treatment,cancer therapy and cancer evolution were also collected in the inflammatory bowel disease ***:Eighteen of 590 patients with inflammatory bowel disease developed cancer[cumulative incidence=3%(95%CI:1.58-4.52)vs 2%(95%CI:1.99-2.11)in the background population;RR=1.5;95%CI:0.97-2.29].The cancer incidence among inflammatory bowel disease patients was 0.53%(95%CI:0.32-0.84)per patient-year of *** with inflammatory bowel disease had a significantly increased relative risk of urothelial carcinoma(RR=5.23,95%CI:1.95-13.87),appendiceal mucinous cystadenoma(RR=36.6,95%CI:7.92-138.4),neuroendocrine carcinoma(RR=13.1,95%CI:1.82-29.7)and rectal carcinoid(RR=8.94,95%CI:1.18-59.7).Colorectal cancer cases were not ***:The overall risk of cancer did not significantly increase in our inflammatory bowel disease ***,there was an increased risk of urinary bladder cancer and,with less statistical power,an increased risk of appendiceal mucinous cystadenoma and of neuroendocrine *** cancer risk was low in our series.
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