A New Route for Preparation of β-TCP/ PLLA Composite

作     者：Feng ZHANG Fang MEI Xin Zhi WANG Xiao Yang HU Yong Ming LUO Xu Liang DENG 

作者机构：School and Hospital of Stomatology Peking University Beijing 100081 Department of Histology and Embryology Health Science Center Peking University Beijing 100083 Department of Environmental Science and Engineering Kunming University of Science and Technology Kunming 650093 The 2nd Hospital of Beijing Armed Police Forces Beijing 100037 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2006年第17卷第6期

页      面：833-836页

核心收录：

学科分类：1003[医学-口腔医学] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 100302[医学-口腔临床医学] 10[医学] 

基　　金：We gratefully acknowledge the support of this research work by National High Technology Research and Development Program of China (No. 2003AA302220, 2004AA304G50) the National Natural Science Foundation of China (No. 30471907) 

主　　题：β-TCP particles β-TCP/PLLA composite dental pulp cells dental tissue engineering. 

摘      要：A new facile route for preparation of β-TCP/PLLA composites is reported in this letter. SEM images display that β-TCP particles with average diameter of 400 nm were well bonded and distributed within the pore walls of the PLLA scaffolds. The mixture of the novel complex and human dental pulp cells was transplanted subcutaneously into the dorsal surface of a nude mouse. Two months later histological examination showed that new collagen and new dentin formed. The results revealed that the new nano β-TCP/PLLA composite combined with human pulp cells could induce dentin formation offering a new way to dental tissue engineering.