Effect of surgical castration on risk factors for arteriosclerosis of patients with prostate cancer

作     者：徐涛 王晓峰 侯树坤 朱积川 张小东 黄晓波 XU Tao;WANG Xiaofeng;HOU Shukun;ZHU Jichuan;ZHANG Xiaodong;HUANG Xiaobo

作者机构：北京大学人民医院泌尿科北京100044 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2002年第115卷第9期

页      面：1336-1340,148-149页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100214[医学-肿瘤学] 10[医学] 

主　　题：Aged Arteriosclerosis Humans Hyperinsulinism Insulin Resistance Lipids Male Middle Aged Orchiectomy Prostatic Neoplasms Risk Factors 

摘      要：OBJECTIVE: To analyze the effect of castration on risk factors for arteriosclerosis of patients with prostate cancer. METHODS: Thirty patients with primary regional prostate adenocarcinoma limited to the prostate theca were selected in this study. Serum levels of testosterone (T), free testosterone (FT), dehydroepiandrosterone (DHEA), sex hormone-binding globulin (SHBG), prostatic specific antigen (PSA), triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), apoprotein alpha(1) (APOalpha(1)) and apoprotein beta (APObeta), insulin, plasma fibrinopeptide A (FPA), plasminogen activator inhibitor-1 (PAI-1) and fibrinogen were determined just prior to, 1 week and 1, 4 and 8 months after castration. RESULTS: T, FT and PSA decreased significantly 1 week after castration (21.12 +/- 15.11 ng/ml vs 383.9 +/- 62.6 ng/ml, P